|1.||Wakamatsu, Kazumasa: 9 articles (05/2015 - 12/2002)|
|2.||Ito, Shosuke: 7 articles (05/2015 - 12/2002)|
|3.||Panzella, Lucia: 6 articles (01/2015 - 07/2010)|
|4.||Napolitano, Alessandra: 6 articles (01/2015 - 07/2010)|
|5.||Simon, John D: 4 articles (02/2014 - 01/2003)|
|6.||Warren, Warren S: 4 articles (02/2014 - 02/2011)|
|7.||d'Ischia, Marco: 3 articles (09/2014 - 07/2010)|
|8.||Simpson, Mary Jane: 3 articles (02/2014 - 02/2011)|
|9.||Wilson, Jesse W: 3 articles (02/2014 - 06/2011)|
|10.||Kågedal, Bertil: 3 articles (09/2010 - 09/2007)|
|1.||Melanoma (Melanoma, Malignant)
11/15/2012 - "Selective absence of pheomelanin synthesis was protective against melanoma development. "
01/01/2015 - "Pheomelanin has been implicated in the increased susceptibility to UV-induced melanoma for people with light skin and red hair. "
09/01/2014 - "Pheomelanin-induced oxidative stress: bright and dark chemistry bridging red hair phenotype and melanoma."
03/01/2014 - "The highest incidence of melanoma in red haired individuals is attributed to the synthesis and phototoxic properties of pheomelanin pigments. "
08/01/2013 - "Uncovering the mechanistic pathway between pheomelanin and oxidative DNA damage will be an important step in developing strategies to lower melanoma risk in redheads. "
11/16/2010 - "Consequently, researchers have worked to elucidate the chemistry of pheomelanin to determine whether the pigment could cause these cancers and, if so, by what mechanisms. "
11/16/2010 - "Epidemiological studies of skin and ocular cancers suggest that increasing relative proportions of pheomelanin correlate with increased risk factors for these diseases. "
06/01/2013 - "This may be especially relevant to detect pheomelanin in animal skin including humans, where it has been associated with animal appearance and classification, human phototypes, prevention of skin diseases and cancer risk."
06/01/2005 - "By contrast, based on measurements of eumelanin and pheomelanin in human skin, before and following irradiation, we now report that both pheomelanin and eumelanin are positively related to skin colour, and by inference, inversely with cancer susceptibility. "
11/16/2010 - "The photoactivation of oxygen by pheomelanin in the UV-A range could contribute to the development of UV-induced cancers: recent measurement of the surface photoionization threshold of intact melanosomes reveals a lower photoionization potential for pheomelanin than eumelanin. "
|3.||Neoplasm Metastasis (Metastasis)
01/01/1988 - "5-S-Cysteinyldopa (5-S-CD), a pheomelanin precursor, has been used as a biochemical marker of melanoma metastasis. "
04/01/1994 - "To establish a better method for the detection of occult melanoma this study compares the plasma levels of a pheomelanin metabolite, 5-S-CD, and a eumelanin metabolite, 6-hydroxy-5-methoxyindole-2-carboxylic acid (6H5MI2C), in melanoma and non-melanoma patients and correlates them with tumor thickness and melanoma metastasis. "
03/01/1993 - "Specifically, we will discuss that: 1) the synthesis of pheomelanin is markedly increased in malignant melanoma and dysplastic melanocytic nevi; 2) high levels of metabolites of pheomelanin and eumelanin can be detected in the urine and blood of patients with metastatic melanoma; 3) this release of melanin metabolites appears to correlate with tumor thickness and tumor load, including the extent of metastasis; 4) the synthesis of melanosomal proteins also becomes aberrant in malignant melanoma; and 5) this abnormal melanosome synthesis can be utilized in the identification of antigenic epitopes that are uniquely expressed in malignant melanoma. "
|5.||Noise-Induced Hearing Loss (Acoustic Trauma)
|4.||DNA (Deoxyribonucleic Acid)
|5.||Reactive Oxygen Species (Oxygen Radicals)
|6.||Biological Markers (Surrogate Marker)
|10.||Monophenol Monooxygenase (Tyrosinase)