alkannin

11/01/2016 - "β,β-dimethylacryloyl alkannin (DMA) is a key component of Lithospermum and possesses good efficacy for treating psoriasis. "
01/01/2015 - "Mice treated with alkannin at varying concentration showed obvious remission in psoriasis-like skin lesion compared to control group, with decreased PASI score, obviously reduced vertical thickness of epidermis. "
11/01/2016 - "Suppressive effect of β,β-dimethylacryloyl alkannin on activated dendritic cells in psoriasis by the TLR7/8 pathway."
01/01/2015 - "To investigate the effect of β, β-dimethylacryloyl alkannin, a main component of Lithospermum erythrorhizon, on activated dendritic cells (DCs) in a psoriasis mouse model. "
01/01/2015 - "β, β-dimethylacryloyl alkannin could suppress the function of activated DCs in imiquimod-induced psoriasis mouse model."

08/01/2023 - "In this study, alkannin selectivity is reported to be significantly improved following structural modification, and derivative 23 is first shown to be able to inhibit lung cancer growth via the PKM2/STAT3 phosphorylation signaling pathway in vitro, indicating the potential value of derivative 23 in treating lung cancer."
08/01/2023 - "Our study aimed to ameliorate the toxicity of alkannin through structural modification and elucidate the mechanism of the superior derivative 23 in lung cancer therapy. "

01/01/2019 - "Here, we explored the efficacy of alkannin in the treatment of Candida vaginitis after external beam radiotherapy. "
01/01/2019 - "Thermosensitive hydrogels as a controlled release system for alkannin to improve localized treatment of Candida vaginitis after external beam radiotherapy in vitro and in vivo."

10/01/2020 - "In the present study, we isolated alkannin from Arnebia euchroma and found that alkannin induced cytotoxic autophagy and apoptosis in many types of cancer cells in a dose-dependent manner. "
08/01/2023 - "Anti-tumor effects of novel alkannin derivatives with potent selectivity on comprehensive analysis."
01/01/2023 - "Alkannin reduced CSCC tumor growth in a mouse xenograft model. "
07/01/2022 - "Alkannin (ALK) is derived from Alkanna tinctoria and is known to exert anti-tumor effects. "
10/01/2020 - "Moreover, alkannin enhanced the sensitivity of cancer cells to chemotherapeutic agents. "

10/01/2020 - "In summary, our study highlights the significant broad-spectrum antitumor effects of alkannin and reveals an important mechanism by which alkannin induces cytotoxic autophagy and apoptosis by promoting ROS-mediated mitochondrial dysfunction and activation of the JNK pathway."
10/01/2020 - "Alkannin induces cytotoxic autophagy and apoptosis by promoting ROS-mediated mitochondrial dysfunction and activation of JNK pathway."