testololactone

01/01/1994 - "Curiously, testololactone was earlier and more widely used than aminoglutethimide in treating advanced breast carcinoma. "
08/01/1982 - "Estrogen synthesis in human breast tumor and its inhibition by testololactone and bromoandrostenedione."
05/01/1980 - "Inhibition of estrogen synthesis in human breast tumors by testololactone and bromoandrostenedione."
12/31/1962 - "[Behavior of serum lactic dehydrogenase (LDH) in disseminated breast cancer treated with delta-1-testololactone]."
01/01/1994 - "Aminoglutethimide and testololactone may be considered the first generation aromatase inhibitors for the endocrine treatment of breast carcinoma. "

05/01/1980 - "Estrone and estradiol synthesis from androstenedione was reduced in 3 tumor incubations by the presence of 0.13 mM delta 1-testololactone and testololactone. "
08/01/1982 - "Estrone and estradiol synthesis from androstenedione was reduced in five tumor incubations by the presence of 0.2 mM delta 1-testololactone and testololactone, 6 alpha- and 6 beta-bromoandrostenedione (2.0 microM) were also shown to block estrogen synthesis in 5 tumors. "

03/01/1975 - "Substitution of theophylline and chlorothiazide for the testololactone in Januray 1974 was followed by further diminution of the measurable abdominal and pelvic desmoids. "