ozolinone

active metabolite of etozolin; RN refers to (Z)-isomer; structure in first source

Also Known As:

3-methyl-4-oxo-5-piperidinothiazolidine-2-ylidine acetic acid; ozolinone, (Z)-(+)-isomer; ozolinone, (Z)-(-)-isomer

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - ozolinone: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - ozolinone: 4

Related Diseases

1.	Renal Insufficiency (Renal Failure) 01/01/1980 - "It is concluded that in the single dose experiments renal insufficiency does not significantly influence the metabolization of etozolin and ozolinone." 01/01/1980 - "Even in severe renal insufficiency the HL of etozolin and ozolinone did not differ from normal values, the mean HL of etozolin being 2.8 +/- 0.4 h and of ozolinone being 10.2 +/- 1.5 h. "
2.	Liver Cirrhosis (Hepatic Cirrhosis) 12/01/1987 - "The results suggest that acute hepatitis and hepatic cirrhosis lead to a reduced formation of ozolinone. " 12/01/1987 - "The single dose kinetics of (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)acetate (etozolin) and its active metabolite ozolinone were determined in 6 healthy volunteers, in 12 patients with acute hepatitis and in 15 patients with hepatic cirrhosis with ascites. " 12/01/1987 - "Altered kinetics of etozolin and its active metabolite ozolinone in hepatitis and hepatic cirrhosis with ascites."
3.	Kidney Diseases (Kidney Disease) 01/01/1980 - "The lack of correlation between elimination half-life (HL) and creatinine clearance showed that there is no influence of kidney disease on the pharmacokinetic parameters of etozolin and ozolinone. "
4.	Hypertension (High Blood Pressure) 01/01/1982 - "The low placental and fetal concentrations of etozolin and ozolinone suggest that these drugs may prove useful when a diuretic is indicated in the treatment of oedema and hypertension during pregnancy."
5.	Hepatitis 12/01/1987 - "The results suggest that acute hepatitis and hepatic cirrhosis lead to a reduced formation of ozolinone. " 12/01/1987 - "In cirrhosis, the plasma level time curves of etozolin and ozolinone differed significantly from the controls and also from those of the patients with acute hepatitis. " 12/01/1987 - "The single dose kinetics of (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)acetate (etozolin) and its active metabolite ozolinone were determined in 6 healthy volunteers, in 12 patients with acute hepatitis and in 15 patients with hepatic cirrhosis with ascites. " 12/01/1987 - "Altered kinetics of etozolin and its active metabolite ozolinone in hepatitis and hepatic cirrhosis with ascites."

Related Drugs and Biologics

1.	etozolin
2.	Furosemide (Lasix)
3.	Diuretics
4.	Creatinine
5.	Bumetanide (Bumex)
6.	azosemide
7.	piretanide