|1.||Coticchia, Christine M: 2 articles (06/2009 - 09/2004)|
|2.||Deb, Tushar B: 2 articles (06/2009 - 09/2004)|
|3.||Dickson, Robert B: 2 articles (06/2009 - 09/2004)|
|4.||Jan, C R: 2 articles (11/2000 - 10/2000)|
|5.||Salas, Valentina: 1 article (01/2015)|
|6.||Langenaken, C: 1 article (01/2015)|
|7.||Raeman, F: 1 article (01/2015)|
|8.||Vanhoof, J: 1 article (01/2015)|
|9.||Lenaerts, J: 1 article (01/2015)|
|10.||Remans, J: 1 article (01/2015)|
01/01/2000 - "In cancers, expression of wild-type exon 3 (w3), exon 5 (w5), and exon 7 (w7) was detected in 93.5%, 93.5%, and 91.3% of ER alpha protein (pER) positive cases, respectively, and 27.8%, 38.9%, and 44.4% in negative cases, respectively (p < 0.0001, p = 0.0035, and p = 0.0002). "
01/01/1986 - "TPA-induced skin tumor promotion was also suppressed by W-7. "
01/01/2001 - "ER variants of the 21PT type were detected among breast cancer biopsy specimens, emphasizing the significance of an alternative therapeutic target for TAM-resistant ER (+) human breast cancers with compounds such as W7."
01/01/1991 - "These findings raise the possibility that W-7 may have clinical value in the prevention of cancer metastasis."
01/01/1991 - "Injection of W-7 i.v. after removal of the implanted primary tumor caused the greatest inhibition of development of lung metastases. "
10/01/1994 - "The effect of 50 microM W-7 was additive to that of a submaximal (20 min) hypoxia stimulus, indicating that W-7 does not interfere with the stimulation of glucose transport by hypoxia. "
07/01/1986 - "Addition of trifluoperazine (5 X 10(-7) M) and W7 (5 X 10(-7) M to both PST and CCT cells during the 2-hr reflow period after 45 min of anoxia increased viability by 58 +/- 3 and 62 +/- 3%, respectively (P less than .05) at 5 hr postanoxia.(ABSTRACT TRUNCATED AT 250 WORDS)"
05/01/1986 - "W-7 (5 X 10(-6) M) and chlorpromazine (10(-6) M) did not affect the AH intervals before hypoxia. "
05/01/1986 - "W-5, a chlorine-deficient derivative of W-7, showed no protection against hypoxia-induced AV nodal conduction disturbances. "
10/01/1994 - "This study was performed to describe the interactions between the effects of W-7 and those of hypoxia and of insulin on glucose transport. "
07/01/2007 - "In adrenalectomized rats, W-7 was also effective in reduction of paw edema (52%). "
12/01/1994 - "When applied before irradiation, W7 and TFP prevented edema in Skh-1 mice and W7 prevented UV-induced edema in NSA mice in a dose-dependent manner. "
07/01/2007 - "Treatment of animals with W-7 reduced carrageenan-induced paw edema by 50%. "
07/01/2007 - "The aim of present study was to investigate the effect of W-7, a calmodulin antagonist, on carrageenan-induced rat's paw edema. "
07/01/2007 - "Our findings suggest that W-7 as a calmodulin inhibitor reduce carrageenan-induced paw edema and the inhibitory effect of W-7 on edema formation appears not to be dependent on adrenal function."
|4.||Hypertension (High Blood Pressure)
02/01/1989 - "The suppressive magnitudes in these responses by W-7 were significantly greater in the mesenteric vasculatures of the DOCA-salt hypertension than in those of the control rats. "
12/01/1991 - "The comparable IC50 of W-7 to inhibit cell growth of vascular smooth muscle cells of both origins indicates that the defect may not be due only to calmodulin, and furthermore suggests the involvement of a previously-reported calmodulin activator in hypertension."
01/01/1988 - "The marked reduction in norepinephrine overflow and pressor responses by W-7 might suggest the greater calmodulin-dependent adrenergic transmission in this model of hypertension."
08/01/1990 - "Although i.v. injection of the drugs did not produce any effect, infusion of W-7 or KN-62 into the 4th ventricle produce any effect, infusion of W-7 or KN-62 into the 4th ventricle of the rat caused hypertension and tachycardia, associated with the diminished rate of GABA release in cerebrospinal fluid. "
02/01/1989 - "Further, it is suggested that the marked reduction in stimulation-evoked norepinephrine overflow and vasoconstrictor responses by W-7 showed the greater calmodulin-dependent regulation in the vascular adrenergic activity of DOCA-salt hypertension."
01/01/2011 - "W-7 pretreatment decreased TUNEL positive cells to 15.0 ± 2.5 and 20.0 ± 2.9 at 24 and 48 hrs after injection compared to the non-pretreated seizure group (P<0.01), but the number of TUNEL positive cells in the W-7 pretreatment group remained significantly greater than in the control group (P<0.01). "
01/01/2011 - "[Effects of W-7 on the expression of GRP78 and neuronal apoptosis in immature rat hippocampus after status convulsion]."
01/01/2011 - "The expression of GRP78 mRNA and protein in the W-7 pretreatment group was significantly higher than both the control and the non-pretreated seizure groups 24 and 48 hrs after injection. "
01/01/2011 - "To investigate the effects of the calmodulin inhibitor W-7 on the expression of the key marker of ERS GRP78 and neuronal apoptosis in the immature rat hippocampus after status convulsion (SC). "
09/17/1993 - "W-7 did not protect against PTX and kainic acid convulsions and 30% of protection was observed against convulsions at the highest dose of W-7 (75 mg/kg).(ABSTRACT TRUNCATED AT 250 WORDS)"
|1.||N- (6- aminohexyl)- 1- naphthalenesulfonamide (W-5)
|3.||Calmodulin (Calcium-Dependent Activator Protein)