tetramethylpyrazine

09/01/1994 - "The present study also showed that ligustrazine and salvia compound have protective effects against reperfusion injury. "
07/01/2012 - "Objective to investigate the protective effects of Ligustrazine preconditioning against hepatic ischemia/reperfusion injury (IRI) in rats. "
01/01/2002 - "These findings suggest that ligustrazine has protective effects against ischemia-reperfusion injury in rat kidneys."
01/01/2002 - "Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys."
03/01/2020 - "In order to further elucidate the molecular mechanism underlying its occurrence, the role of nucleotide‑binding oligomerization domain‑containing 2 (NOD2) in AKI was investigated in the present study, and the results indicated that ligustrazine exerts an important protective effect against AKI in vivo by inhibiting the upregulation of NOD2 expression and reducing apoptosis of kidney cells following ischemia/reperfusion injury in rat models. "

10/01/2019 - "The study was to investigate the effects of ligustrazine on rats with cerebral ischemia-reperfusion (I/R) injury and to explore the potential mechanism. "
05/01/2007 - "To study the effect of ligustrazine on the migration of neuronal precursors (NPs) after focal cerebral ischemia in adult rats and explore its acting mechanism on recovery of function. "
12/01/2003 - "To study the protective effect of Ligustrazine on IR after local cerebral ischemia of rat. "
12/01/1992 - "With the animal model of cerebral ischemia and reperfusion, we conducted experiments on such model to study the effects of Ligustrazine(LZ) and Salvia Miltirrhizae(SM). "
11/01/2022 - "However, the molecular mechanisms of ligustrazine in cerebral ischemia/reperfusion (I/R) damage have not been clear elucidated. "

03/01/2020 - "To the best of our knowledge, the results of the present study are the first to provide evidence that ligustrazine can inhibit NOD2‑mediated inflammation to protect against renal injury, which may be in part attributed to the induction of autophagy. "
01/01/2019 - "The purpose of the study was to evaluate the effect of Astragalus membranaceus extract and ligustrazine combination on ameliorating inflammation in cerebral ischemic rats that have undergone thrombolysis. "
12/01/2023 - "It suggests ligustrazine reduces inflammation response and mitochondria-dependent apoptosis induced by THS in liver Kupffer cells and promotes more survival effects by elevating the Akt pathway. "
12/01/2023 - "Ligustrazine inhibited inflammation in EMs via regulating the STAT3/IGF2BP1/RELA axis. "
12/01/2023 - "Ligustrazine also alleviated RELA-induced inflammation via downregulating IGF2BP1. "

07/01/2023 - "Tetramethylpyrazine significantly improved the motor function of the hind limbs of mice after spinal cord injury, and the BMS score and inclined plate test score of the tetramethylpyrazine high-dose group were significantly higher than those of the model group(P<0.01). "
08/15/2016 - "Micro-CT as a Tool to Investigate the Efficacy of Tetramethylpyrazine in a Rat Spinal Cord Injury Model."
11/01/2023 - "Tetramethylpyrazine promotes angiogenesis and nerve regeneration and nerve defect repair in rats with spinal cord injury."
04/15/2023 - "Effects of tetramethylpyrazine treatment in a rat model of spinal cord injury: A systematic review and meta-analysis."
10/01/2021 - "TAT-modified tetramethylpyrazine-loaded nanoparticles for targeted treatment of spinal cord injury."

01/01/2015 - "A modified "double-hit" induced acute lung injury model in rats and protective effects of tetramethylpyrazine on the injury via Rho/ROCK pathway."
01/01/2022 - "Tetramethylpyrazine ameliorates acute lung injury by regulating the Rac1/LIMK1 signaling pathway."
01/01/2021 - "Ligustrazine Alleviate Acute Lung Injury Through Suppressing Pyroptosis and Apoptosis of Alveolar Macrophages."
01/01/2023 - "Dual Delivery of Tetramethylpyrazine and miR-194-5p Using Soft Mesoporous Organosilica Nanoparticles for Acute Lung Injury Therapy."
02/01/2012 - "To investigate the effects of ligustrazine on acute lung injury induced by blunt chest trauma. "