2-cresolphthalexon

RN given refers to parent cpd

Also Known As:

2-cresolphthalexon, tetrasodium salt; cresolphthalein complexone; o-cresolphthalexon; ortho-cresolphthalexon; N,N'-((3-oxo-1(3H)-isobenzofuranylidene)bis((6-hydroxy-5-methyl-3-,1-phenylene)methylene))bis(N-(carboxymethyl)glycine)

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Phenolphthaleins: 2
        2-cresolphthalexon: 3

Experts

1.	Kurozumi, Akira: 1 article (01/2019)
2.	Nakano, Kazuhisa: 1 article (01/2019)
3.	Nakayamada, Shingo: 1 article (01/2019)
4.	Okada, Yosuke: 1 article (01/2019)
5.	Tanaka, Yoshiya: 1 article (01/2019)
6.	Yamagata, Kaoru: 1 article (01/2019)
7.	Song, Zhe: 1 article (12/2016)
8.	Wang, Xian: 1 article (12/2016)
9.	Xu, Ming-Jiang: 1 article (12/2016)
10.	Zhao, Yang: 1 article (12/2016)

Related Diseases

1.	Vascular Calcification 12/25/2016 - "Vascular calcification of abdominal aorta was identified by o-cresolphthalein complexone copper assay and Von Kossa staining. " 01/01/2019 - "Our results demonstrated: (1) interleukin-6 (IL-6)/soluble interleukin-6 receptor (sIL-6R) induced transformation of hVSMCs into an osteoblast phenotype, with subsequent vascular calcification, based on the results of Alizarin Red S staining and O-Cresolphthalein complexone method; (2) IL-6/sIL-6R accelerated the expression of runt-related transcription factor 2 (RUNX2) based on the results of quantitative real-time polymerase chain reaction; (3) Knockdown of signal transducer and activator of transcription (STAT) 3 reduced IL-6/sIL-6R-induced RUNX2 mRNA expression and osteoblast transdifferentiation of hVSMCs; (4) Chromatin immunoprecipitation (ChIP) coupled with PCR (ChIP-PCR) identified a STAT-binding site in RUNX2 promoter region containing trimethylated histone 3 lysine 9 (H3K9me3), a transcriptional repressor, and H3K4me3, a transcriptional enhancer. "
2.	Hemolysis 03/01/1990 - "Methods using a single, alkaline cresolphthalein complexone reagent are most seriously affected by haemolysis due to persistence of oxyhaemoglobin. "

Related Drugs and Biologics

1.	Interleukin-6 Receptors (Interleukin 6 Receptor)
2.	Interleukin-6 (Interleukin 6)
3.	Transcription Factors (Transcription Factor)
4.	Messenger RNA (mRNA)
5.	Lysine (L-Lysine)
6.	Indicators and Reagents (Reagents)
7.	Histones (Histone)
8.	Copper
9.	Chromatin
10.	Alizarin Red S