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9-(tetrahydro-2-furyl)-adenine

Also Known As:

SQ 22536; SQ-22,536; SQ-22536; Sq 22,536; 9-(tetrahydro-2-furanyl)-9H-purin-6-amine

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Adenine: 2120
        9-(tetrahydro-2-furyl)-adenine: 9

Experts

1.	Huo, Fuquan: 1 article (01/2020)
2.	Liu, Junlin: 1 article (01/2020)
3.	Wang, Yangdong: 1 article (01/2020)
4.	Wu, Yanan: 1 article (01/2020)
5.	Yan, Chunxia: 1 article (01/2020)
6.	Yang, Jingsi: 1 article (01/2020)
7.	Yang, Xixi: 1 article (01/2020)
8.	Zhang, Yuxiang: 1 article (01/2020)
9.	Bordignon, Juliano: 1 article (11/2017)
10.	Carvalho de Freitas, Rafael: 1 article (11/2017)

Related Diseases

1.	Hypoxia (Hypoxemia) 08/15/2009 - "(2) Adenylate cyclase inhibition (SQ-22536; 80 microm) inhibited the hypoxic release response (>50%) and did not affect acidic/hypercapnic release, evidencing that the high gain of hypoxia to elicit neurotransmitter release is cAMP dependent. " 12/01/2005 - "Hypoxia activated much more KIR currents in symmetrical 140 K+. This effect was blocked by the adenylyl cyclase inhibitor SQ-22536 (10 microM) and mimicked by forskolin (10 microM) and dibutyryl-cAMP (500 microM). "
2.	MELAS Syndrome (Syndrome, MELAS) 01/01/1991 - "The adenosine analogue 9-(Tetrahydro-2-furyl)adenine, SQ 22536, inhibited adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] activity of crude membrane preparations from catfish (Ictalurus melas) and rat isolated hepatocytes in a non-competitive manner. "
3.	Periodontitis 12/01/2009 - "Parotid glands from rats with periodontitis showed an increase in cAMP levels that was also reverted in the presence of SQ 22536, FR 122047 and VIP 6-28. "
4.	Osteolysis 04/01/1990 - "We have used two new inhibitors of adenylate cyclase, 9-(tetrahydro-2-furyl)adenine (SQ 22536) and 2',5'-dideoxyadenosine (DDA), to directly reassess the role of cAMP in PTH-stimulated osteolysis. "
5.	Neuralgia (Stump Neuralgia) 01/01/2020 - "Furthermore, the anti-nociceptive effect of EMD-386088 on neuropathic pain was prevented by the adenylate cyclase (AC) inhibitor SQ-22536, and protein kinase A (PKA) inhibitor H89, suggesting that AC/PKA signaling might underlie the antinociception of agonists. "

Related Drugs and Biologics

1.	Adenylyl Cyclases (Adenylyl Cyclase)
2.	2',5'-dideoxyadenosine
3.	bis(p-chlorophenyl)acetic acid (DDA)
4.	Neurotransmitter Agents (Neurotransmitter)
5.	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
6.	Colforsin
7.	Buserelin (Suprefact)
8.	Adenosine (Adenocard)
9.	5- chloro- 2- methyl- 3- (1,2,3,6- tetrahydro- 4- pyridinyl)- 1H- indole
10.	vasoactive intestinal peptide (6-28)