Ricinus communis agglutinin-1

120 kDa lectin from castor bean; less toxic than RICIN; RCA 60 = RICIN

Also Known As:

RCA (120) lectin; RCA-120 Ricinus lectin; RCA120 Ricinus lectin; Ricinus communis agglutinin; ricinus agglutinin; ricinus lectins

Networked: 92 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Lectins: 6782
    - Plant Lectins: 206
      - Ricinus communis agglutinin-1: 92
  - Plant Proteins: 334
    - Plant Lectins: 206
      - Ricinus communis agglutinin-1: 92

Experts

1.	Bulte, Jeff W M: 1 article (10/2018)
2.	Liang, Yajie: 1 article (10/2018)
3.	Walczak, Piotr: 1 article (10/2018)
4.	Zhang, Jiangyang: 1 article (10/2018)
5.	Hardisty, Jerry F: 1 article (01/2013)
6.	Harris, Nancy: 1 article (01/2013)
7.	Kolenda-Roberts, Holly Meredith: 1 article (01/2013)
8.	Singletary, Emily: 1 article (01/2013)
9.	El Rassi, Ziad: 1 article (07/2012)
10.	Selvaraju, Subhashini: 1 article (07/2012)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 07/01/2012 - "Tandem lectin affinity chromatography monolithic columns with surface immobilised concanavalin A, wheat germ agglutinin and Ricinus communis agglutinin-I for capturing sub-glycoproteomics from breast cancer and disease-free human sera." 08/01/1988 - "In primary and metastatic breast carcinomas, lectin receptor sites were stained more intensely with Concanavalia ensiformi agglutinin (*Con A), Ricinus communis agglutinin-I (RCA-I) and wheat germ agglutinin (WGA), than in normal breast, in mastopathies or in fibroadenomas. " 04/01/1984 - "Two forms of alpha 1-acid glycoprotein with common immunological determinants and almost identical amino acid compositions but different amounts of carbohydrate were isolated from liver metastases of primary colon, lung, and breast tumors by extraction with perchloric acid, gel filtration on Sepharose CL-6B and Sephadex G-200, and affinity chromatography on concanavalin A:agarose and Ricinus communis agglutinin l:agarose. "
2.	Liver Neoplasms (Liver Cancer) 07/01/1989 - "[A study of ricinus communis agglutinin I receptors in liver cancer tissues]." 10/01/1989 - "Using Ricinus communis agglutinin I (RCA-I) affinity crossed-line immunoelectrophoresis, alpha-fetoprotein (AFP) subfractions were studied in sera from patients with primary hepatic cancer (PHC), hepatic metastasis of gastric cancer (HMGC), yolk sac tumor (YST), acute or chronic hepatitis or hepatic cirrhosis. "
3.	Type A Niemann-Pick Disease 01/01/1987 - "Ricinus communis agglutinin-I (RCA-I) stained the glomerular epithelium only in GM1 and MPS-I. Succinylated wheat germ agglutinin (SWGA) stained the glomerular endothelium and epithelium in mannosidosis, and the glomerular epithelium and Bowman's capsule in MPS-I. Ultrastructure studies demonstrated an accumulation of oligosaccharides in cases of mannosidosis and GM1 gangliosidosis, a mixture of oligosaccharides and lipids in MPS-I, MPS-VI and GM2 gangliosidosis and only lipid storage in sphingomyelin lipidosis. "
4.	Mannosidase Deficiency Diseases (Mannosidosis) 01/01/1987 - "Ricinus communis agglutinin-I (RCA-I) stained the glomerular epithelium only in GM1 and MPS-I. Succinylated wheat germ agglutinin (SWGA) stained the glomerular endothelium and epithelium in mannosidosis, and the glomerular epithelium and Bowman's capsule in MPS-I. Ultrastructure studies demonstrated an accumulation of oligosaccharides in cases of mannosidosis and GM1 gangliosidosis, a mixture of oligosaccharides and lipids in MPS-I, MPS-VI and GM2 gangliosidosis and only lipid storage in sphingomyelin lipidosis. "
5.	GM2 Gangliosidoses (GM2 Gangliosidosis) 01/01/1987 - "Ricinus communis agglutinin-I (RCA-I) stained the glomerular epithelium only in GM1 and MPS-I. Succinylated wheat germ agglutinin (SWGA) stained the glomerular endothelium and epithelium in mannosidosis, and the glomerular epithelium and Bowman's capsule in MPS-I. Ultrastructure studies demonstrated an accumulation of oligosaccharides in cases of mannosidosis and GM1 gangliosidosis, a mixture of oligosaccharides and lipids in MPS-I, MPS-VI and GM2 gangliosidosis and only lipid storage in sphingomyelin lipidosis. "

Related Drugs and Biologics

1.	Lectins
2.	Concanavalin A
3.	Wheat Germ Agglutinins
4.	Oligosaccharides
5.	Lipids
6.	succinylated wheat germ agglutinin
7.	Agglutinins
8.	Peanut Agglutinin
9.	Glycoproteins (Glycoprotein)
10.	dolichos biflorus agglutinin

Related Therapies and Procedures

1.	Transplantation
2.	Microspheres (Microsphere)
3.	Injections
4.	Immunotherapy