nitrapyrin (N-serve)

soil bactericide; nitrogen-conserving agent; structure; RN given refers to (+-)-isomer

Also Known As:

N-serve; alpha,alpha,alpha-6-tetrachloro-2-picoline; 2-chloro-6-(trichloromethyl)pyridine

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Picolines: 14
      - nitrapyrin: 3

Experts

1.	LeBaron, Matthew J: 2 articles (01/2021 - 01/2017)
2.	Rasoulpour, Reza J: 2 articles (01/2021 - 01/2017)
3.	Johnson, Kamin: 1 article (01/2021)
4.	LaRocca, Jessica: 1 article (01/2021)
5.	Murphy, Lynea: 1 article (01/2021)
6.	Wang, Xiujuan: 1 article (01/2021)
7.	Eisenbrandt, David L: 1 article (01/2017)
8.	Gollapudi, B Bhaskar: 1 article (01/2017)
9.	LaRocca, Jessica L: 1 article (01/2017)
10.	Murphy, Lynea A: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "In a 2-year oncogenicity study, increased incidence of mice with hepatocellular tumors was observed following exposure to 125 (females only) or 250 mg/kg/day (males and females) nitrapyrin in the diet. " 01/01/2017 - "Evaluation of the data from repeat dose and MoA studies by the Bradford Hill criteria and a Human Relevance Framework (HRF) suggested that nitrapyrin-induced mouse liver tumors are not relevant to human health risk assessment because of qualitative differences between these two species." 01/01/2021 - "Consistent with the liver MoA in male mice, these data support a CAR-mediated mode of action for nitrapyrin-induced liver tumors in female mice, with the understanding that a focused approach minimizing animal use can bridge male and female datasets when sex-specific carcinogenic differences are observed." 01/01/2021 - "Nitrapyrin, a nitrification inhibitor, produces liver tumors in B6C3F1 mice. " 01/01/2017 - "Nitrapyrin, a nitrification inhibitor, produces liver tumors in mice at high doses. "
2.	Sarcoma (Soft Tissue Sarcoma) 06/01/2008 - "Higher incidences of Harderian gland adenomas (females) and undifferentiated sarcomas in the epididymis represented normal biological variations in incidence and were unrelated to nitrapyrin. "
3.	Hypertrophy 01/01/2021 - "Nitrapyrin induced a treatment-related increase in hepatocellular hypertrophy and hepatocellular proliferation. "
4.	Adenoma (Adenomas) 06/01/2008 - "Higher incidences of Harderian gland adenomas (females) and undifferentiated sarcomas in the epididymis represented normal biological variations in incidence and were unrelated to nitrapyrin. "