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6-hydroxy-5-methoxy-2-indolylcarboxylic acid

metabolite found in urine of mammals having melanotic melanoma
Also Known As:
5-methoxy-6-hydroxyindole-2-carboxylic acid; 6-HMICA; 6-hydroxy-5-methoxy-2-indolecarboxylic acid; 6-hydroxy-5-methoxyindole-2-carboxylic acid; 6H5MI2C
Networked: 14 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Ito, Shosuke: 1 article (04/2006)
2. Kageshita, Toshiro: 1 article (04/2006)
3. Kågedal, Bertil: 1 article (04/2006)
4. Takasaki, Akihiko: 1 article (04/2006)
5. Wakamatsu, Kazumasa: 1 article (04/2006)
6. Arndt, R: 1 article (11/2001)
7. Hartleb, J: 1 article (11/2001)
8. Arstrand, K: 1 article (08/2000)
9. Brochez, L: 1 article (08/2000)
10. Kärnell, R: 1 article (08/2000)

Related Diseases

1. Melanoma (Melanoma, Malignant)
2. Neoplasms (Cancer)
3. Neoplasm Metastasis (Metastasis)
02/01/1994 - "Serum concentration and urinary excretion of 5-S-CD and 6H5MI2C in patients with melanoma without metastases were close to those obtained from normal subjects. "
04/01/1994 - "We found a) that the normal plasma levels of 5-S-CD and 6H5M12C are less than 2.22 ng/ml and 1.04 ng/ml, respectively; b) that the group with the normal 6H5MI2C plasma level does not have any metastasis, whereas a normal 5-S-CD level is seen in both non-melanoma and melanoma patients with and without metastasis; c) that a high plasma 6H5MI2C level is seen in all melanoma patients with tumor thickness more than 3.0 mm regardless of the presence or absence of metastasis, whereas in thinner melanoma patients this is seen only in positive metastasis group; and d) that all melanoma patients with positive metastases showed a high plasma 6H5MI2C level (more than 1.75 ng/ml). "
04/01/1994 - "We conclude that the measurement of plasma levels of melanin metabolites provides a method for detecting occult melanoma metastasis and estimating the prognosis of melanoma patients, plasma 6H5MI2C level being more sensitive and reliable than that of 5-S-CD, and its increased level being a high risk factor."
04/01/1994 - "To establish a better method for the detection of occult melanoma this study compares the plasma levels of a pheomelanin metabolite, 5-S-CD, and a eumelanin metabolite, 6-hydroxy-5-methoxyindole-2-carboxylic acid (6H5MI2C), in melanoma and non-melanoma patients and correlates them with tumor thickness and melanoma metastasis. "
4. Psoriasis (Pustulosis Palmaris et Plantaris)

Related Drugs and Biologics

1. 6-hydroxy-5-methoxy-2-indolylcarboxylic acid
2. eumelanin
3. Cysteinyldopa
4. Proteins (Proteins, Gene)
5. pheomelanin
6. phaeomelanin
7. Biomarkers (Surrogate Marker)
8. 5-hydroxy-6-methoxy-2-indolylcarboxylic acid (HMICA)
9. Melanins (Melanin)
10. Acids

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)