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5-hydroxy-6-methoxy-2-indolylcarboxylic acid (HMICA)
metabolite found in urine of mammals having melanotic melanoma
Also Known As:
HMICA
; 5-hydroxy-6-methoxy-2-indolecarboxylic acid; 5H6MI2C; 5-hydroxy-6-methoxyindole-2-carboxylic acid
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
5-hydroxy-6-methoxy-2-indolylcarboxylic acid: 7
Related Diseases
1.
Melanoma (Melanoma, Malignant)
01/01/1988 - "
However, 5H6MI2C had a higher excretion level at the early stage of melanoma progression, while 5-S-CD had a higher excretion level at the later stage.
"
01/01/1988 - "
We measured the urinary excretion of 5H6MI2C and 5-S-CD in mice bearing B16 melanoma to determine which of the two markers better reflects the progression of melanoma.
"
01/01/1990 - "
These results suggest that 5H6MI2C + 6H5MI2C and 5-S-CD in serum may better reflect melanoma progression than those in urine.
"
07/01/1990 - "
Identification of ester glucuronide and sulfate conjugates of 5-hydroxy-6-methoxyindole-2-carboxylic acid and 6-hydroxy-5-methoxyindole-2-carboxylic acid in melanoma urine.
"
01/01/1983 - "
Using gas chromatography--mass spectrometry we were able to identify five indolic compounds in the urine of melanoma patients: 5,6-dihydroxyindole (5,6DHI), 5-hydroxy-6-methoxyindole (5H6MI), 6-hydroxy-5-methoxyindole (6H5MI), and 5-hydroxy-6-methoxyindolyl-2-carboxylic (5H6MI2C) and 6-hydroxy-5-methoxyindolyl-2-carboxylic acids (6H5MI2C).
"
2.
Oculocutaneous Albinism (Albinism, Yellow Mutant)
01/01/1991 - "
Eumelanin and pheomelanin contents in hair and 5-S-cysteinyldopa and 5-hydroxy-6-methoxyindole-2-carboxylic acid levels in urine in Japanese oculocutaneous albinism.
"
07/01/1990 - "
[Eumelanin and pheomelanin contents in hairs of healthy Japanese and patients with oculocutaneous albinism, and 5-S-cysteinyldopa and 5-hydroxy-6-methoxyindole-2-carboxylic acid levels in urine of oculocutaneous albinism].
"
07/01/1987 - "
We measured the urinary excretion of 3,4-dihydroxyphenylalanine (dopa), 5-S-cysteinyldopa (5-S-CD), and 2 indolic compounds, namely 5-hydroxy-6-methoxyindole (5H6MI) and 5-hydroxy-6-methoxyindole-2-carboxylic acid (5H6MI2C) in urine samples of 4 groups of people with different contents of cutaneous melanin: Asian group, white group, and 2 groups of whites 1 with vitiligo and 1 with tyrosinase-negative oculocutaneous albinism.
"
3.
Vitiligo
07/01/1987 - "
We measured the urinary excretion of 3,4-dihydroxyphenylalanine (dopa), 5-S-cysteinyldopa (5-S-CD), and 2 indolic compounds, namely 5-hydroxy-6-methoxyindole (5H6MI) and 5-hydroxy-6-methoxyindole-2-carboxylic acid (5H6MI2C) in urine samples of 4 groups of people with different contents of cutaneous melanin: Asian group, white group, and 2 groups of whites 1 with vitiligo and 1 with tyrosinase-negative oculocutaneous albinism.
"
4.
Neoplasms (Cancer)
01/01/1990 - "
An excellent correlation was found between the serum concentration of 5H6MI2C + 6H5MI2C (r = 0.92) and 5-S-CD (r = 0.89) and tumor weight.
"
5.
Experimental Melanoma
01/01/1988 - "
We measured the urinary excretion of 5H6MI2C and 5-S-CD in mice bearing B16 melanoma to determine which of the two markers better reflects the progression of melanoma.
"
Related Drugs and Biologics
1.
Cysteinyldopa
2.
6-hydroxy-5-methoxy-2-indolylcarboxylic acid
3.
eumelanin
4.
5-hydroxy-6-methoxyindole
5.
pheomelanin
6.
5-hydroxy-6-methoxy-2-indolylcarboxylic acid (HMICA)
7.
Glucuronides
8.
Monophenol Monooxygenase (Tyrosinase)
9.
Sulfates (Sulfates, Inorganic)
10.
Melanins (Melanin)