|1.||Kodaira, Susumu: 5 articles (08/2006 - 11/2002)|
|2.||Ohashi, Yasuo: 4 articles (08/2006 - 04/2004)|
|3.||Ito, K: 4 articles (05/2001 - 02/2000)|
|4.||Tominaga, Takeshi: 3 articles (08/2006 - 04/2004)|
|5.||Yasutomi, Masayuki: 3 articles (08/2006 - 04/2004)|
|6.||Nakamura, T: 3 articles (11/2001 - 09/2000)|
|7.||Takagi, H: 3 articles (05/2001 - 02/2000)|
|8.||Watanabe, Masahiko: 2 articles (08/2006 - 04/2004)|
|9.||Kato, Tomoyuki: 2 articles (08/2006 - 04/2004)|
|10.||Kunitomo, Kazufumi: 2 articles (08/2006 - 04/2004)|
|1.||Colorectal Neoplasms (Colorectal Cancer)
02/01/2000 - "In the second study of patients operated at 7 Centers in the Tokai district between October 1, 1987 and September 30, 1990, 173 patients with colorectal cancer were allocated to two groups after surgery, a control group receiving no HCFU, the other group receiving HCFU at 0.8 mg/kg per day orally, for 1 year, beginning 4 weeks after the operation. "
10/01/1997 - "A prospective controlled study, the 7th cooperative study of the Japanese Foundation for Multidisciplinary Treatment, was conducted to evaluate the usefulness of concomitant therapy with MMC + HCFU as a postoperative adjuvant therapy in patients with colorectal cancer who had undergone curative resection for a period of 2 years and 11 months from February, 1986. "
10/01/1996 - "Tokai HCFU Study Group--third study on colorectal cancer."
01/01/2013 - "Here we show that the antineoplastic drug carmofur, which is used in the clinic to treat colorectal cancers, is a potent AC inhibitor and that this property is essential to its anti-proliferative effects. "
03/01/2001 - "This finding suggests the promising clinical application of oral HCFU for colorectal cancer after curative resection."
|2.||Neoplasm Metastasis (Metastasis)
03/01/2001 - "An animal experimental study was performed to clarify the preventive effect of oral HCFU (1-hexylcarbamoyl-5-fluorouracil) on hepatic metastasis. "
01/01/2006 - "First, S-1 was effective even though this patient had a lung metastasis during adjuvant treatment with HCFU. "
02/01/2000 - "The effectiveness of HCFU in reducing the disease-free survival rate appeared to be mainly due to its preventive effect on distant metastases."
02/01/1989 - "To our knowledge, there has been only one report pertaining to the efficacy of HCFU for treatment of metastatic lung lesion of HCC, so we reported a case of HCC with lung metastasis which responded to chemotherapy with a single use of HCFU. "
02/01/1999 - "Thus, the case suggests that HCFU is useful for the treatment of liver metastases from colorectal cancer."
12/01/1983 - "HCFU might be effective against gynecologic cancers when used in maintenance therapy at a lower dosage (300--400 mg) than previously estimated."
07/01/1987 - "HCFU treatment improved the survival rate of the tumor-bearing mice. "
05/01/1994 - "In the first study by the "Kinki Head and Neck Tumor Study Group," we performed a comparative study to investigate intergroup difference between a control group consisting of patients given radical treatment only, and a HCFU group consisting of patients receiving long-term administration of HCFU after radical treatment. "
01/01/2013 - "Modifications in the chemical scaffold of carmofur yield new AC inhibitors that act synergistically with standard antitumoral drugs to prevent cancer cell proliferation. "
03/01/2001 - "A total of 180 BALB/C mice received intraportal injection of Colon26 cancer cells followed by oral daily administration of HCFU to 5 groups divided according to the dose of HCFU, ranging from 0 (controls) to 7.5 mg/Kg for 21 days. "
|4.||Colonic Neoplasms (Colon Cancer)
09/01/2005 - "We designed an individual patient-based meta-analysis of relevant clinical trials to examine the benefit of oral carmofur for curatively resected colon cancer in terms of overall survival (OS) and disease-free survival (DFS). "
09/01/2005 - "This individual patient-based meta-analysis demonstrated that oral carmofur significantly improves both OS and DFS in patients with curatively resected colon cancers."
09/01/2005 - "An individual patient data meta-analysis of adjuvant therapy with carmofur in patients with curatively resected colon cancer."
10/01/1997 - "The above results suggest that HCFU is useful for patients with a high risk of recurrence who had advanced colon cancer (stage III b + IV). "
08/01/2001 - "As a result, it was suggested that oral adjuvant chemotherapy with HCFU would be effective in colon cancer patients when the duration of administration exceeded 330 days. "
|5.||Stomach Neoplasms (Stomach Cancer)
02/01/1996 - "These results suggested the long-term administration of HCFU was effective for noncuratively resected and unresected gastric cancer."
02/01/1986 - "From the results, it is suggested that carmofur maintenance therapy is effective for the prevention of postsurgical recurrence of stomach cancer by means of the prolongation of patient survival."
02/01/1996 - "To evaluate the efficacy of adjuvant immunochemotherapy, especially the long-term administration of HCFU to patients with noncuratively resected and unresected gastric cancer, a randomized controlled study was conducted by 16 institutions in Hokkaido. "
07/01/1996 - "[Study on the combined preoperative treatment with CDDP and HCFU for gastric cancer]."
06/01/2001 - "[Inhibition of HCFU absorption after resection for gastric cancer--application of hydroxyaluminium gel]."
|5.||raltitrexed (D 1694)
|2.||Drug Therapy (Chemotherapy)
|5.||Transplantation (Transplant Recipients)