|1.||Marcuzzi, Annalisa: 3 articles (10/2012 - 08/2008)|
|2.||Nakaya, Kazuyasu: 3 articles (05/2007 - 01/2003)|
|3.||Aiuchi, Toshihiro: 3 articles (05/2007 - 01/2003)|
|4.||Nakajo, Shigeo: 3 articles (05/2007 - 01/2003)|
|5.||Walter, C: 2 articles (09/2015 - 03/2011)|
|6.||Ziebart, T: 2 articles (09/2015 - 03/2011)|
|7.||Katuru, Rajasekhar: 2 articles (11/2013 - 05/2011)|
|8.||Fernandes, Nicolle V: 2 articles (11/2013 - 05/2011)|
|9.||Mo, Huanbiao: 2 articles (11/2013 - 05/2011)|
|10.||Crovella, Sergio: 2 articles (10/2012 - 05/2011)|
05/29/1997 - "In a previous study, we showed that geranylgeraniol (GGO) is a potent inducer of apoptosis in human leukemia cells. "
05/16/1997 - "In a previous study, we showed that geranylgeraniol (GGO) is a potent inducer of apoptosis in human leukemia cells, including HL60 promyelocytic leukemia cells. "
05/29/1997 - "Geranylgeraniol potently induces caspase-3-like activity during apoptosis in human leukemia U937 cells."
11/01/2000 - "In the present study, we investigated the effects of geranylgeraniol (GGO), a potent inducer of apoptosis in various lines of human tumor cells, on signal transduction cascades involved in apoptosis in human leukemia cells. "
05/01/2007 - "To elucidate the mechanism of induction of apoptosis by geranylgeraniol (GGO), which is a potent inducer of apoptosis in various lines of human cancer cells, we examined the role of intracellular acidification during GGO-induced apoptosis using human leukemia HL60 cells. "
05/01/2011 - "The diterpene geranylgeraniol (all trans-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-ol) suppresses the growth of human liver, lung, ovary, pancreas, colon, stomach and blood tumors with undefined mechanisms. "
07/28/2006 - "Geranylgeraniol (GGO) induces apoptosis in various lines of human tumor cells through a mitochondrion-dependent pathway. "
09/24/1996 - "It was demonstrated recently that geranylgeraniol (GGO) has potent apoptosis-inducing activity in various lines of tumor cells, including HL-60 cells. "
01/01/1995 - "Geranylgeraniol is a potent inducer of apoptosis in tumor cells."
05/01/2011 - "Geranylgeraniol may have potential in cancer chemoprevention and/or therapy."
10/01/2012 - "In our study we have investigated the apoptotic mechanism mediated by the exposure of the cultured neuroblastoma cell line, SH-SY5Y, to lovastatin in absence or in presence of the isoprenoid, geranylgeraniol, with the aim of unraveling the pathogenesis of MA. "
10/01/2012 - "Lovastatin-induced apoptosis is modulated by geranylgeraniol in a neuroblastoma cell line."
06/01/2013 - "N-BPs reduce Oc bone resorption by inhibiting the enzyme farnesyl diphosphate synthase (FPPS), an effect counteracted by geranylgeraniol (GGOH), which restores geranylgeranylation downstream of FPPS. "
12/01/2001 - "Furthermore, when cells were treated with either alendronate alone or in combination with Z-VAD-FMK for 24 or 48 h, subsequent addition of geranylgeraniol, which restores geranylgeranylation, returned bone resorption to control levels. "
01/05/1999 - "Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro."
05/01/1999 - "The inhibitory effect of ibandronate on bone resorption could be totally reversed by the addition of geranylgeraniol and to a small extent only by mevalonate and farnesol, indicating that the bisphosphonate acts at a level of the mevalonate pathway different from that of mevastatin. "
|5.||Osteonecrosis (Kienbock's Disease)
09/01/2015 - "Geranylgeraniol (GGOH) has been reported as a potential treatment option for bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ). "
05/01/2011 - "Comments on ''Geranylgeraniol--a new potential therapeutic approach to bisphosphonate associated osteonecrosis of the jaw" by Ziebart T et al. (2011)."
03/01/2011 - "Geranylgeraniol - a new potential therapeutic approach to bisphosphonate associated osteonecrosis of the jaw."
|1.||Vitamin K 2 (Vitamin K2)
|5.||Mevalonic Acid (Mevalonate)
|7.||Cytochromes c (Cytochrome c)
|8.||Alendronate (Alendronate Sodium)