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folate-binding protein

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RefSeq NM_016731 (human)

Also Known As:

FOLR1 protein, human; MOv18 protein, human; folate binding protein; folate carrier; folate receptor; folate receptor 1 (adult), human; folate-methotrexate transporter; folic acid binding protein; folic acid receptor; folic acid receptor beta; methotrexate-binding protein

Networked: 407 relevant articles (17 outcomes, 47 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 58309
  - Carrier Proteins: 7706
    - folate-binding protein: 407
  - Membrane Proteins: 4071
    - Cell Surface Receptors: 547
      - folate-binding protein: 407

Experts

1.	Low, Philip S: 33 articles (01/2010 - 05/2002)
2.	Lee, Robert J: 20 articles (01/2010 - 01/2002)
3.	Leamon, Christopher P: 19 articles (09/2009 - 11/2002)
4.	Ratnam, Manohar: 12 articles (12/2009 - 07/2002)
5.	Reddy, Joseph A: 12 articles (09/2009 - 11/2002)
6.	Westrick, Elaine: 10 articles (09/2009 - 03/2005)
7.	Schibli, Roger: 10 articles (12/2008 - 05/2006)
8.	Müller, Cristina: 9 articles (08/2008 - 05/2006)
9.	Vetzel, Marilynn: 8 articles (09/2009 - 11/2002)
10.	Lu, Yingjuan: 8 articles (09/2009 - 05/2002)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2004 - "The improvement in yield of the targeting component can significantly facilitate "scale up" of folate receptor-mediated liposomal cancer therapy to the preclinical and clinical levels of investigations." 12/01/2004 - "Folate receptor-targeted cancer therapies constitute a promising treatment for the approximately one third of human cancers that overexpress the folate receptor (FR). " 06/01/2008 - "Exploratory study of 99mTc-EC20 imaging for identifying patients with folate receptor-positive solid tumors." 09/01/2006 - "We report the development and in vitro study of a nanoconjugate serving as a targeted magnetic resonance imaging (MRI) contrast enhancement agent for detection of cancer cells overexpressing the folate receptor. " 11/02/2005 - "This study suggests the potential of using folate-receptor-mediated delivery of rev-caspase-3 gene for inducing tumor cell death in a target-specific manner." Order ALL the reference details at left...
2.	Carcinoma (Carcinomatosis) 11/01/2008 - "BACKGROUND: The goal of this study was to evaluate the expression pattern and intracellular localization of alpha-folate receptor (alpha-FR) protein in human ovarian carcinoma compared with non-neoplastic ovarian tissue. " 11/01/2008 - "Alpha-folate receptor expression in epithelial ovarian carcinoma and non-neoplastic ovarian tissue." 02/28/2008 - "RESULTS: Flow cytometry showed that the expression of folate receptor (FR), EC109 (C), DCs (D) in human nasopharyngeal carcinoma cell line (HNE1) (B) was 78.21%, 89.50%, and 0.18%, respectively. " 11/01/2007 - "Flow cytometric method for determining folate receptor expression on ovarian carcinoma cells." 03/15/2005 - "Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay." Order ALL the reference details at left...
3.	Ovarian Neoplasms (Ovarian Cancer) 03/01/2010 - "Farletuzumab (MORAb-003) is a humanized mAb with high affinity for folate receptor alpha (FRalpha), a 38 kDa GPI-anchored protein that is overexpressed in 90% of epithelial ovarian cancers. " 01/01/2009 - "The folate receptor alpha (FRalpha) is one logical choice for a biomarker because of its prevalent overexpression in ovarian cancer and its exclusive expression in only a few normal tissues. " 01/01/2009 - "Functional folate receptor alpha is elevated in the blood of ovarian cancer patients." 10/15/2006 - "EXPERIMENTAL DESIGN AND RESULTS: Interactions of measles virus with its natural receptors were ablated, and a single-chain antibody (scFv) specific for alpha-folate receptor (FRalpha), a target overexpressed on 90% of nonmucinous ovarian cancer, was genetically engineered on the viral attachment protein (MV-alphaFR). " 10/15/2006 - "The use of a tropism-modified measles virus in folate receptor-targeted virotherapy of ovarian cancer." Order ALL the reference details at left...
4.	Adenocarcinoma 10/01/2007 - "Overexpression of folate binding protein is associated with shortened progression-free survival in uterine adenocarcinomas." 06/01/1994 - "Folate receptor of human mammary adenocarcinoma." 06/15/1999 - "High-affinity folate receptor in human ovary, serous ovarian adenocarcinoma, and ascites: radioligand binding mechanism, molecular size, ionic properties, hydrophobic domain, and immunoreactivity." 08/01/1995 - "In this study, we have examined the in vivo activity of murine T cells transduced with a chimeric receptor gene (MOv-gamma) derived from the mAb MOv18, which binds to a folate-binding protein overexpressed on most human ovarian adenocarcinomas. " 04/01/1998 - "The presence of a folate binding protein which immunoreacts with antibodies against human milk folate binding protein was demonstrated in ascitic fluids from seven patients with ovarian adenocarcinoma. " Order ALL the reference details at left...
5.	Rheumatoid Arthritis 07/01/2007 - "Folate receptor is overexpressed on the activated (but not quiescent) macrophages in both animal models and human patients with naturally occurring rheumatoid arthritis. " 04/29/2004 - "Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis." 10/01/2006 - "In vitro and in vivo efficacy of a recombinant immunotoxin against folate receptor beta on the activation and proliferation of rheumatoid arthritis synovial cells." 01/01/2009 - "Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients." 09/01/2005 - "Effectiveness of anti-folate receptor beta antibody conjugated with truncated Pseudomonas exotoxin in the targeting of rheumatoid arthritis synovial macrophages." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Folic Acid (Vitamin M)
2.	Liposomes (Liposome)
3.	Antigens
4.	Antibodies
5.	Paclitaxel (Taxol)
6.	Micelles
7.	Immunoglobulin G (IgG)
8.	Arsenic
9.	Proteins (Proteins, Gene)
10.	Immunoglobulin E (IgE)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Immunotherapy
3.	Lasers (Laser)
4.	Neutron Capture Therapy
5.	Drug Therapy (Chemotherapy)

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