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7-ethoxycoumarin
Networked:
16
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
Coumarins: 826
7-ethoxycoumarin: 16
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
Coumarins: 826
7-ethoxycoumarin: 16
Experts
1.
Kulikova, L N
: 1 article (05/2004)
2.
Lee, S H
: 1 article (12/2000)
3.
Lee, S M
: 1 article (12/2000)
4.
Lee, Y G
: 1 article (12/2000)
Related Diseases
1.
Liver Diseases (Liver Disease)
07/01/1985 - "
The metabolism of 7-ethoxycoumarin in human liver microsomes and the effect of primary biliary cirrhosis: implications for studies of drug metabolism in liver disease.
"
08/01/1979 - "
The activity of 7-ethoxycoumarin 0-deethylase and associated NADPH-cytochrome c reductase was determined in 9000 g supernatant from bioptically obtained liver specimens from patients with various liver diseases in order to study in vitro drug metabolising capacity.
"
2.
Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)
07/01/1985 - "
Using 7-ethoxycoumarin as a probe substrate, microsomal monoxygenase activity has been measured in liver tissue from patients with primary biliary cirrhosis (PBC) of varying histological severity, and in histologically normal control tissue.
"
07/01/1985 - "
The metabolism of 7-ethoxycoumarin in human liver microsomes and the effect of primary biliary cirrhosis: implications for studies of drug metabolism in liver disease.
"
3.
Starvation
10/12/1990 - "
7-Ethoxycoumarin O-dealkylation and aniline hydroxylation activities of the renal microsomes of control male rats were very low but were induced 2.5-3-fold by 72 h starvation.
"
04/01/1990 - "
P450 DM (P450j) was induced 2.5-fold by a 48-h starvation and its increase reflected the increase of metabolic activity of hepatic microsomes toward aniline, 7-ethoxycoumarin, and N-nitrosodimethylamine.
"
05/01/1986 - "
The cytochrome P-450 content in liver cells from rainbow trout was not affected by starvation for 12 weeks whereas the rate of cytochrome P-450-dependent deethylation of 7-ethoxycoumarin in liver cells from 6 or 12 weeks starved fish was 60% of the rate in fed fish.
"
4.
Infections
05/26/2023 - "
7-Ethoxycoumarin rescued Caenorhabditis elegans from infection of COPD derived clinical isolate Pseudomonas aeruginosa through virulence and biofilm inhibition via targeting Rhl and Pqs quorum sensing systems.
"
06/01/1986 - "
During infection, 7-ethoxycoumarin deethylase (7ECdeEt'ase) and ethylmorphine demethylase (EMdeMe'ase) (monooxygenases), and NADPH cytochrome c reductase (NADPH c red'ase) were measured in liver microsomes.
"
5.
Hepatocellular Carcinoma (Hepatoma)
05/01/2004 - "
Microsomes isolated from hepatoma 61 transplanted to mice treated with either pyrazole or cobalt chloride catalyzed oxidation of coumarin and 7-ethoxycoumarin at rates 2-2.5-fold higher than in saline controls.
"
01/01/1985 - "
The carbon monoxide-reduced difference spectral peak of hepatoma P-450MCI was at 446.5 nm, whereas the peak of hepatoma P-450MCII was at 451 nm. In the reconstituted system, hepatoma P-450MCI catalyzed 3-hydroxylation of benzo[a]pyrene and O-deethylation of 7-ethoxycoumarin, but showed low activities for N-demethylation of benzphetamine and aminopyrine, O-demethylation of p-nitroanisole, and p-hydroxylation of aniline.
"
Related Drugs and Biologics
1.
NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)
2.
Cytochrome P-450 Enzyme System (Cytochrome P450)
3.
aniline (aniline hydrobromide)
4.
Benzphetamine (Benzfetamine)
5.
Benzo(a)pyrene
6.
Aminopyrine (Aminophenazone)
7.
Glucuronides
8.
Xenobiotics
9.
Sulfates (Sulfates, Inorganic)
10.
NADP (NADPH)