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2,4-diaminopyrimidine

Networked: 9 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - 2,4-diaminopyrimidine: 9

Experts

1.	Alaa Eldin Refat, Lamis: 1 article (05/2022)
2.	Erxleben, Andrea: 1 article (05/2022)
3.	McArdle, Patrick: 1 article (05/2022)
4.	O'Malley, Ciaran: 1 article (05/2022)
5.	Simmie, John M: 1 article (05/2022)
6.	Fang, Yu: 1 article (01/2021)
7.	Gao, Hang: 1 article (01/2021)
8.	Li, Ye: 1 article (01/2021)
9.	Qi, Yueheng: 1 article (01/2021)
10.	Qiang, Bingchao: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 10/15/2020 - "Aiming to identify new optimization strategy effective for ALK-mutations, two series of pyrroformyl-containing 2,4-diaminopyrimidine compounds (11a-o, 12a-o) were designed, synthesized and evaluated for their anti-proliferative activities against three cancer cell lines in vitro by MTT assay. " 01/01/2021 - "A series of 2,4-diaminopyrimidine derivatives were labeled with 18F to study their biological properties and their potential as positron emission tomography tumor imaging agents. " 12/01/2023 - "In this study, twenty-one novel 2,4-diaminopyrimidine cinnamyl derivatives as inhibitors targeting FAK were designed and synthesized based on the structure of TAE-226, and the inhibitory effects of these compounds on both the FAK enzyme and three cancer cell lines (MGC-803, HCT-116, and KYSE30) were investigated. " 01/01/2021 - "Design, Synthesis, Biological Evaluation, and Molecular Docking of 2,4-Diaminopyrimidine Derivatives Targeting Focal Adhesion Kinase as Tumor Radiotracers."
2.	Malaria 01/01/1980 - "Pyrimethamine, a 2,4-diaminopyrimidine useful in the treatment of malaria and toxoplasmosis, was found to enhance antibody and delayed-type hypersensitivity responses to sheep red cells in mice. " 05/04/2022 - "The malaria drug pyrimethamine (pyr) and the antibiotic trimethoprim (tmp) are both 2,4-diaminopyrimidine derivatives, providing the same C-NH2/N=C/C-NH2 and C-NH2/N=C interaction sites. "
3.	Toxoplasmosis 01/01/1980 - "Pyrimethamine, a 2,4-diaminopyrimidine useful in the treatment of malaria and toxoplasmosis, was found to enhance antibody and delayed-type hypersensitivity responses to sheep red cells in mice. "
4.	Hypersensitivity (Allergy) 01/01/1980 - "Pyrimethamine, a 2,4-diaminopyrimidine useful in the treatment of malaria and toxoplasmosis, was found to enhance antibody and delayed-type hypersensitivity responses to sheep red cells in mice. "
5.	Triple Negative Breast Neoplasms 01/01/2015 - "Herein we demonstrated the design and optimization of a series of hybrid of 2,4-diaminopyrimidine and arylthiazole derivatives for their anti-proliferative properties against two breast cancer cell lines (MCF-7 as human breast cancer and MDA-MB-231 as triple-negative breast cancer). " 03/15/2023 - "Design, synthesis and evaluation of nitric oxide releasing derivatives of 2,4-diaminopyrimidine as novel FAK inhibitors for intervention of metastatic triple-negative breast cancer." 03/15/2023 - "To search for novel medicines for intervention of triple-negative breast cancer (TNBC), a series of phenylsulfonyl furoxan-based 2,4-diaminopyrimidine derivatives (8a-t) were designed and synthesized based on blocking FAK-mediated signaling pathways through both kinase-dependent and -independent manners. "

Related Drugs and Biologics

1.	Pyrimethamine (Daraprim)
2.	Enzymes
3.	Focal Adhesion Protein-Tyrosine Kinases
4.	Trimethoprim (Proloprim)
5.	Thymidine Monophosphate (TMP)
6.	Phosphotransferases (Kinase)
7.	Nitric Oxide (Nitrogen Monoxide)
8.	NADP (NADPH)
9.	Folic Acid (Vitamin M)
10.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Therapeutics