|1.||Ling, Shucai: 2 articles (01/2015 - 01/2015)|
|2.||Fang, Marong: 2 articles (01/2015 - 01/2015)|
|3.||Hu, Zhiying: 2 articles (01/2015 - 01/2015)|
|4.||Li, Weiyun: 2 articles (01/2015 - 01/2015)|
|5.||Yang, Yang: 2 articles (01/2015 - 01/2015)|
|6.||Dong, Ning: 2 articles (11/2002 - 04/2002)|
|7.||Yu, Yan: 2 articles (11/2002 - 04/2002)|
|8.||Winchester, W J: 1 article (05/2015)|
|9.||Bulmer, D C: 1 article (05/2015)|
|10.||Wheeldon, A: 1 article (05/2015)|
04/01/2002 - "The prognosis of the scalding rats complicated by sepsis caused by G(+) bacteria could be improved by DAHP pretreatment, which might be related to the inhibition of the production of BH(4) and NO by DAHP."
11/01/2002 - "Fifty-six male Wistar rats were randomly divided into four groups as follows: normal control group (n = 10), scald control group (n = 10), postburn sepsis group (n = 20), and DAHP treatment group (n = 16). "
04/01/2002 - "normal control, scalding control, postburn sepsis group and DAHP treatment group. "
11/01/2002 - "The objective of present study was to observe the effect of 2,4-diamino-6-hydroxy-pyrimidine (DAHP), an inhibitor of GTP-CHI, on the development of postburn Staphylococcus aureus sepsis. "
11/01/2002 - "Early treatment with DAHP might be a potential strategy to prevent the development of postburn Staphylococcal sepsis, which appears to be associated with down-regulation of biopterin and nitric oxide formation by DAHP."
|2.||Brain Ischemia (Cerebral Ischemia)
01/01/2015 - "However, the protective effects of TP and DAHP on cerebral ischemia have not been reported yet. "
01/01/2015 - "These results demonstrate that TP and DAHP can decrease cell apoptosis in focal cerebral ischemia rat brains and that the mechanism may be related to the activation of the PI3K/Akt/mTOR pathway and inactivation of the ERK1/2 pathway. "
01/01/2015 - "Autophagy upregulation and apoptosis downregulation in DAHP and triptolide treated cerebral ischemia."
01/01/2015 - "Neuroprotective effects of DAHP and Triptolide in focal cerebral ischemia via apoptosis inhibition and PI3K/Akt/mTOR pathway activation."
01/01/2015 - "Thus our hypothesis was reached PI3K/Akt/mTOR and ERK1/2 pathways may provide distinct cellular targets for a new generation of therapeutic agents for the treatment of stroke, and TP and DAHP may be potential neuroprotective agents for cerebral ischemia/reperfusion injury. "
|3.||Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
01/01/2015 - "In this study, we investigated the neuroprotective effects of TP and DAHP in a middle cerebral artery occlusion (MCAO) rat model. "
01/01/2015 - "2, 4-diamino-6-hydroxy-pyrimidine (DAHP), for its nitric oxide synthase (NOS) inhibiting neuroprotective effect, and triptolide (TP), for its anti-inflammatory property, were selected to administer pre middle cerebral artery occlusion (MCAO). "
05/01/2015 - "In rodents pretreatment with DAHP produced a substantial dose related inhibition of pain behaviors from 10 to 180 mg/kg i.p. "
05/01/2015 - "GCH-1 is strongly implicated in chronic pain based on data generated using the selective GCH-1 inhibitor 2,4-diamino-6-hydroxypyrimidine (DAHP), and studies which have identified a pain protective GCH-1 haplotype associated with lower BH4 production and reduced pain. "
05/01/2015 - "To investigate the role for GCH-1 in visceral pain we examined the effects of DAHP on pain behaviors elicited by colorectal injection of mustard oil in rats, and the pain protective GCH-1 haplotype in healthy volunteers characterized by esophageal pain sensitivity before and after acid injury, and assessed using depression and anxiety questionnaires. "
12/01/2012 - "We assessed the effects of the GCH1 inhibitor diaminohydroxypyrimidine (DAHP) on nociception and inflammation in a mouse melanoma and a sarcoma cancer pain model, and its co-effects with morphine in terms of analgesic efficacy and respiratory depression. "
12/01/1974 - "Accordingly, the possibility was examined that mis-regulation of DAHP synthetase by l-phenylalanine in wild-type cells causes starvation for precursors of the other aromatic end products. "
08/01/1980 - "In addition, it was demonstrated that starvation for certain amino acids led to degradation of tyrosine-repressible DAHP synthetase, but not phenylalanine-repressible DAHP synthetase, and supplementation with the missing amino acid led to an increased rate of synthesis of tyrosine-repressible DAHP synthetase during subsequent growth."
|1.||Guanosine Triphosphate (GTP)
|4.||Nitric Oxide (Nitrogen Monoxide)
|8.||NG-Nitroarginine Methyl Ester (L-NAME)
|9.||Nitric Oxide Synthase (NO Synthase)