coelenterazine

active group in AEQUORIN, a coelenterate luciferin

Also Known As:

2-(4-hydroxybenzyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo(1,2-a)pyrazin-3-one; Imidazo(1,2-a)pyrazin-3(7H)-one, 6-(4-hydroxyphenyl)-2-((4-hydroxyphenyl)methyl)-8-(phenylmethyl)-

Networked: 18 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - coelenterazine: 18
  - Pyrazines: 150
    - coelenterazine: 18

Experts

1.	Bronsart, Laura L: 2 articles (04/2016 - 01/2016)
2.	Contag, Christopher H: 2 articles (04/2016 - 01/2016)
3.	Stokes, Christian: 2 articles (04/2016 - 01/2016)
4.	Tannous, Bakhos A: 2 articles (01/2016 - 03/2012)
5.	Weissleder, Ralph: 2 articles (03/2012 - 10/2003)
6.	Pichler, Andrea: 2 articles (06/2005 - 02/2004)
7.	Piwnica-Worms, David: 2 articles (06/2005 - 02/2004)
8.	Prior, Julie L: 2 articles (06/2005 - 02/2004)
9.	Correia, Ana Salomé: 1 article (09/2021)
10.	Duarte, Diana: 1 article (09/2021)

Related Diseases

1.	Glioma (Gliomas) 10/09/2003 - "HSV amplicon vectors bearing the genes for TRAIL and Rluc injected directly into Gli36fluc(+)-expressing subcutaneous gliomas revealed peak Rluc activity 36 h after intratumoral injection as determined by coelenterazine injection followed by imaging. " 03/21/2012 - "We engineered glioma cells to express this reporter and showed that brain tumor formation can be temporally imaged by bioluminescence following systemic administration of coelenterazine. " 10/09/2003 - "Using dual substrate/reporter bioluminescence imaging (Fluc: firefly luciferase-luciferin and Rluc: Renilla luciferase-coelenterazine), we tested the efficacy of TRAIL using replication-deficient herpes simplex virus (HSV) type 1 amplicon vectors in gliomas. "
2.	Melanoma (Melanoma, Malignant) 07/01/2012 - "A significant reduction of the number of live melanoma cells in vitro and a borderline significant retardation of tumour growth in vivo was observed after coelenterazine-mediated PDT."
3.	Ischemia 10/01/2005 - "This review illustrates the therapeutic potential of synthetic imidazolopyrazinones (coelenterazine analogues): chemical reactivity assays with singulet oxygen, radical anion superoxide, peroxynitrite, and radicals formed during lipid and LDL peroxidation, cellular tests of protection against oxidative stress using keratinocyte, hepatocyte, neuronal and erythrocyte cells, and finally in vivo evaluation in a hamster model of ischemia-reperfusion, are fully described."
4.	Infections 11/01/2002 - "On the negative side, this technique has also some disadvantages: (i) the relatively low amount of emitted light makes difficult performing single-cell imaging studies; (ii) reconstitution of aequorin with coelenterazine requires previous complete depletion of Ca(2+) of the ER for 1-2h, a maneuver that may result in deleterious effects in some cells; (iii) because of the high rate of aequorin consumption at steady-state [Ca(2+)](ER), only relatively brief experiments can be performed; and (iv) expression of ER-targeted aequorin requires previous transfection or infection to introduce the appropriate DNA construct, or alternatively the use of stable cell clones. " 11/01/2008 - "On the negative side, this technique has also some disadvantages: (i) the relatively low amount of emitted light makes difficult performing single-cell imaging studies; (ii) reconstitution of aequorin with coelenterazine is necessary to generate the functional photoprotein and this procedure requires at least 1h; (iii) in the case of aequorin targeted to high Ca2+ compartments, because of the high rate of aequorin consumption at steady-state, only relatively brief experiments can be performed and, because of the steepness of the Ca2+-response curve, the calibrated [Ca2+] values may not reflect the real mean in cells or compartments with dyshomogeneous behavior; and (iv) expression of targeted aequorins requires previous transfection or infection to introduce the appropriate DNA construct, or alternatively the use of stable cell clones."
5.	Neoplasms (Cancer) 02/10/2004 - "Therefore, using coelenterazine and noninvasive bioluminescence imaging in vivo, we could directly monitor tumor-specific Pgp transport inhibition in living mice. " 01/01/2016 - "Upon intravenous injection of rGluc followed by its substrate coelenterazine, non-invasive visualization of tumor vascularity by bioluminescence imaging was possible. " 04/01/2016 - "4T1 murine mammary adenocarcinoma tumors in mice demonstrated significantly higher 2.13 ± 0.19-fold coelenterazine-based chemiluminescence than that of surrounding normal tissues. " 09/11/2021 - "In conclusion, the present results indicate that the application of the heavy-atom effect to marine coelenterazine could be a promising approach for the future development of new and optimized self-activating and tumor-selective sensitizers for light-free PDT." 12/19/2017 - "Novel coelenterazine-type bioluminescent probes have been designed and synthesized to detect nitroreductase (NTR) in hypoxic tumors. "

Related Drugs and Biologics

1.	Renilla Luciferases
2.	Superoxides (Superoxide)
3.	1-phenyl-3,3-dimethyltriazene (PDT)
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	Firefly Luciferases
6.	Peroxynitrous Acid (Peroxynitrite)
7.	Lipids
8.	Anions
9.	Luciferins
10.	oxidized low density lipoprotein

Related Therapies and Procedures

1.	Intravenous Injections