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coelenterazine

active group in AEQUORIN, a coelenterate luciferin
Also Known As:
2-(4-hydroxybenzyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo(1,2-a)pyrazin-3-one; Imidazo(1,2-a)pyrazin-3(7H)-one, 6-(4-hydroxyphenyl)-2-((4-hydroxyphenyl)methyl)-8-(phenylmethyl)-
Networked: 12 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Weissleder, Ralph: 2 articles (03/2012 - 10/2003)
2. Pichler, Andrea: 2 articles (06/2005 - 02/2004)
3. Prior, Julie L: 2 articles (06/2005 - 02/2004)
4. Piwnica-Worms, David: 2 articles (06/2005 - 02/2004)
5. Chen, Ching-Wen: 1 article (01/2013)
6. Hsu, Chia-Yen: 1 article (01/2013)
7. Lin, Yan-Fu: 1 article (01/2013)
8. Yu, Hsiu-Ping: 1 article (01/2013)
9. Lai, Ping-Shan: 1 article (01/2013)
10. Bossmann, Stefan H: 1 article (07/2012)

Related Diseases

1. Glioma (Gliomas)
2. Melanoma (Melanoma, Malignant)
3. Ischemia
4. Infection
11/01/2008 - "On the negative side, this technique has also some disadvantages: (i) the relatively low amount of emitted light makes difficult performing single-cell imaging studies; (ii) reconstitution of aequorin with coelenterazine is necessary to generate the functional photoprotein and this procedure requires at least 1h; (iii) in the case of aequorin targeted to high Ca2+ compartments, because of the high rate of aequorin consumption at steady-state, only relatively brief experiments can be performed and, because of the steepness of the Ca2+-response curve, the calibrated [Ca2+] values may not reflect the real mean in cells or compartments with dyshomogeneous behavior; and (iv) expression of targeted aequorins requires previous transfection or infection to introduce the appropriate DNA construct, or alternatively the use of stable cell clones."
11/01/2002 - "On the negative side, this technique has also some disadvantages: (i) the relatively low amount of emitted light makes difficult performing single-cell imaging studies; (ii) reconstitution of aequorin with coelenterazine requires previous complete depletion of Ca(2+) of the ER for 1-2h, a maneuver that may result in deleterious effects in some cells; (iii) because of the high rate of aequorin consumption at steady-state [Ca(2+)](ER), only relatively brief experiments can be performed; and (iv) expression of ER-targeted aequorin requires previous transfection or infection to introduce the appropriate DNA construct, or alternatively the use of stable cell clones. "
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Luciferases
2. 1-phenyl-3,3-dimethyltriazene (PDT)
3. Peroxynitrous Acid (Peroxynitrite)
4. Superoxides (Superoxide)
5. Oxygen
6. DNA (Deoxyribonucleic Acid)
7. Aequorin
8. Renilla Luciferases
9. Tacrolimus Binding Proteins (FKBP)
10. P-Glycoprotein