|1.||Boss, Gerry R: 6 articles (09/2015 - 09/2006)|
|2.||Pilz, Renate B: 2 articles (06/2011 - 09/2006)|
|3.||Brenner, Matthew: 2 articles (06/2011 - 04/2010)|
|4.||Bigby, Timothy D: 2 articles (06/2011 - 08/2010)|
|5.||Mahon, Sari B: 2 articles (06/2011 - 04/2010)|
|6.||Chan, Adriano: 2 articles (06/2011 - 08/2010)|
|7.||Blackledge, William: 2 articles (08/2010 - 04/2010)|
|8.||Sharma, Vijay S: 2 articles (04/2010 - 09/2006)|
|9.||Wassenaar, Jean W: 1 article (09/2015)|
|10.||Christman, Karen L: 1 article (09/2015)|
06/01/2011 - "The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning."
08/01/2010 - "Cobinamide is superior to other treatments in a mouse model of cyanide poisoning."
06/01/2011 - "The combination of cobinamide and sulfanegen shows great promise as a new approach to treating cyanide poisoning."
04/01/2010 - "Intramuscular cobinamide sulfite rapidly and effectively reverses the physiologic effects of cyanide poisoning, suggesting that a compact cyanide antidote kit can be developed for mass casualty cyanide exposures."
09/01/2015 - "Cobinamide is being developed as an IM injectable treatment for cyanide poisoning, and we found that the in vitro binding data correlated with previously published in vivo drug absorption in animals. "
09/01/2006 - "Using a well-established model of bacterial sepsis in Drosophila melanogaster, we found that cobinamide, a B(12) analog and an effective NO scavenger in vitro, dramatically improved fly survival. "
09/01/2006 - "The nitric oxide scavenger cobinamide profoundly improves survival in a Drosophila melanogaster model of bacterial sepsis."
12/01/2014 - "Blood cyanide concentrations became undetectable at the end of the study in both antidote-treated groups, and no statistically significant differences were detected between the 2 groups for mean arterial pressure, cardiac output, respiratory rate, lactate, or pH. Both hydroxocobalamin and cobinamide rescued severely cyanide-poisoned swine from apnea in the absence of assisted ventilation. "
12/01/2014 - "Our objective is to compare the time to return of spontaneous breathing in swine with acute cyanide-induced apnea treated with intravenous hydroxocobalamin, intravenous cobinamide, or saline solution (control). "
|4.||Exocrine Pancreatic Insufficiency
06/01/1978 - "We have tested this hypothesis by determining the ability of a nonradioactive Cbl analogue, bound with high affinity by R protein but not by IF, to correct the malabsorption of [(57)Co]Cbl in patients with pancreatic insufficiency.R protein bound the Cbl analogue known as cobinamide with affinities that were the same and only 14-fold lower than those for Cbl at pH 8 and pH 2, respectively. "
06/01/1978 - "The oral administration of 100 nmol of nonradioactive cobinamide in Schilling tests was equivalent to trypsin in its ability to completely correct the malabsorption of 0.4 nmol of [(57)Co]Cbl in three patients with pancreatic insufficiency. "
06/01/1978 - "The fact that both trypsin and nonradioactive cobinamide inhibit the ability of R protein to compete with IF for [(57)Co]Cbl binding in vitro, and correct the mal-absorption of [(57)Co]Cbl in patients with pancreatic insufficiency in vivo, supports our hypothesis that the primary defect in Cbl absorption in this disease is an inability to partially degrade R protein because of a lack of pancreatic proteases."
|1.||Vitamin B 12 (Cyanocobalamin)
|5.||Sodium Chloride (Saline Solution)
|6.||Peptide Hydrolases (Proteases)
|7.||Nitric Oxide (Nitrogen Monoxide)