carbobenzoxyphenylalanine

RN given refers to (L-Phe)-isomer

Also Known As:

Z-Phe; benzyloxycarbonylphenylalanine; carbobenzoxyphenylalanine, (D-Phe)-isomer; carbobenzoxyphenylalanine, (DL-Phe)-isomer; carbobenzoxyphenylalanine, sodium salt, (L-Phe)-isomer

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Essential Amino Acids: 1152
    - Phenylalanine: 4090
      - carbobenzoxyphenylalanine: 11
  - Cyclic Amino Acids: 3
    - Aromatic Amino Acids: 467
      - Phenylalanine: 4090
        carbobenzoxyphenylalanine: 11

Experts

1.	Ansaldi, Christelle: 1 article (01/2022)
2.	Bassissi, Firas: 1 article (01/2022)
3.	Baudoin, Jean-Pierre: 1 article (01/2022)
4.	Bestion, Eloïne: 1 article (01/2022)
5.	Brun, Sonia: 1 article (01/2022)
6.	Courcambeck, Jérôme: 1 article (01/2022)
7.	Decaens, Thomas: 1 article (01/2022)
8.	Drouot, Cyrille: 1 article (01/2022)
9.	Halfon, Philippe: 1 article (01/2022)
10.	Hamaï, Ahmed: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 10/15/2014 - "Further, intraperitoneally disseminated tumor could be visualized in real time in vivo by fluorescence endoscopy after spraying Z-Phe-Arg-HMRG, with a T/B ratio of 3. In conclusion, our HMRG-based activatable probes targeted to cathepsins have expanded the detectable range of cancers, and appear to be suitable for clinical application. " 10/15/2014 - "Z-Phe-Arg-HMRG showed higher applicability than Z-Arg-Arg-HMRG for in vivo imaging, and we confirmed that 0.5-mm-sized SK-OV-3 tumor nodules disseminated on the mesentery in a mouse model could be rapidly visualized by Z-Phe-Arg-HMRG, with a T/B fluorescence ratio of 4.2. " 01/01/1996 - "Cathepsin B activity was estimated in serum using Z-Phe-Arg-NMec, and in tumor tissue using Z-Arg-Arg-pNA . " 05/01/2020 - "For carboxypeptidase A from the untransformed tissue of the mammalian gland Km=0,24 mM and Ki=0,40 mM were determined, for carboxypeptidase A from the malignant neoplasm of the mammalian gland - Km=0,17 mM and Ki=0,65 mM. Carboxypeptidase A from the untransformed tissue and malignant neoplasm of the mammalian gland is identical as to the substrate specificity, inhibition by phenylalanine for noncompetitive type, inhibition and activation effect by reagent with the exclusion of soybean trypsin inhibitor and PMSF, but differ as to affinity to carbobenzoxyphenylalanine and sensitivity to phenylalanine."
2.	Peripheral Nerve Injuries 02/19/2014 - "We herein show that inhibition of cathepsin S (CatS) activity, either through genetic deletion or via a pharmacological inhibitor, Z-Phe-Leu-COCHO (Z-FL), significantly attenuated the maintenance of tactile allodynia, splenic hypertrophy, increased number of splenic CD4(+) T-cells and the final cleavage step of the MHC class II-associated invariant chain following peripheral nerve injury. "
3.	Cholangiocarcinoma 01/01/2022 - ": ANXA5:annexin A5; ATCC: American type culture collection; BafA1: bafilomycin A1; BSA: bovine serum albumin; CASP3: caspase 3; CASP7: caspase 7; CASP8: caspase 8; CCND1: cyclin D1; CTSB: cathepsin B; CTSD: cathepsin D; CTSL: cathepsin L; CQ: chloroquine; iCCA: intrahepatic cholangiocarcinoma; DEN: diethylnitrosamine; DMEM: Dulbelcco's modified Eagle medium; FBS: fetal bovine serum; FITC: fluorescein isothiocyanate; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; HCC: hepatocellular carcinoma; HCQ: hydroxychloroquine; HDSF: hexadecylsulfonylfluoride; IC50: mean half-maximal inhibitory concentration; LAMP: lysosomal associated membrane protein; LC3-II: phosphatidylethanolamine-conjugated form of MAP1LC3; LMP: lysosomal membrane permeabilization; MALDI: matrix assisted laser desorption ionization; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MKI67: marker of proliferation Ki-67; MTOR: mechanistic target of rapamycin kinase; MRI: magnetic resonance imaging; NH4Cl: ammonium chloride; NtBuHA: N-tert-butylhydroxylamine; PARP: poly(ADP-ribose) polymerase; PBS: phosphate-buffered saline; PPT1: palmitoyl-protein thioesterase 1; SD: standard deviation; SEM: standard error mean; vs, versus; Zn2+: zinc ion; Z-Phe: Z-Phe-Tyt(tBu)-diazomethylketone; Z-VAD-FMK: carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]- fluoromethylketone."
4.	Periodontitis 08/01/1991 - "The activities of cathepsin B- and L-like proteinases in homogenised gingival tissue from control and periodontitis patients were measured biochemically using the selective peptide substrate Z-Phe-Arg-AFC and the selective cathepsin L inhibitor Z-Phe-Phe-CHN2. "
5.	Infections 07/05/2002 - "Infection of both L929 cells treated with the cathepsin L inhibitor Z-Phe-Tyr(t-Bu)-diazomethyl ketone and cathepsin L-deficient mouse embryo fibroblasts resulted in inefficient proteolytic disassembly of viral outer-capsid proteins and decreased viral yields. "

Related Drugs and Biologics

1.	Cathepsin L
2.	Cathepsin B
3.	Peptides (Polypeptides)
4.	Peptide Hydrolases (Proteases)
5.	Cathepsins
6.	arginylarginine (Arg-Arg)
7.	benzyloxycarbonylphenylalanylphenylalanine diazomethyl ketone
8.	Cathepsin H
9.	Caspase 8 (Caspase-8)
10.	Caspase 7

Related Therapies and Procedures

1.	Lasers (Laser)