butyrylcholine

10/01/2021 - "Overexpression of cholinesterases has been emphatically connected to 'Alzheimer's disease because of the unreasonable hydrolysis of acetylcholine and butyrylcholine. "
06/01/2018 - "The present study suggests that rivastigmine might improve appetite in mild-to-moderate Alzheimer's disease patients by suppressing degradation of plasma active ghrelin through the inhibition of plasma butyrylcholine esterase. "
06/01/2018 - "Rivastigmine is a therapeutic agent for Alzheimer's disease that has dual inhibition effects on acetylcholine esterase and butyrylcholine esterase. "
03/01/2016 - "Inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), which breakdown acetylcholine and butyrylcholine, are considered as a promising strategy in the management of Alzheimer's disease (AD). "
09/04/1990 - "We used acetylcholine and butyrylcholine to competitively inhibit the cleavage of acetylthiocholine or butyrylthiocholine in plaques and tangles of Alzheimer's disease. "

08/01/1980 - "Benextramine only inhibited the contracture caused by carbachol or butyrylcholine. "
04/01/2002 - "ACh induced concentration-dependent smooth tonic contractures coupled with considerable depolarisation from the normal resting membrane potential of -30.6 mV. The use of choline ester analogues such as carbachol, propionylcholine and butyrylcholine, specific cholinergic agonists such as nicotine, muscarine, bethanecol and pilocarpine and antagonists such as d-tubocurarine, succinylcholine, hexamethomium, atropine, gallamine, pirenzepine and scopolamine indicated that the ACh receptor showed both nicotinic and muscarinic characteristics; the muscarinic activity resembled that of a mammalian M(2)-like receptor. "

05/01/1972 - "1. The iontophoretic application of acetylcholine (ACh) on to identified neurones in the buccal ganglion of the mollusc Navanax produced a biphasic or monophasic membrane potential change which was a function of the current intensity and site of ACh application.2. Low iontophoretic currents, 200 msec in duration, applied to the somatic surface facing the neuropile, caused a monophasic potential change of 6-10 sec duration, which had a reversal potential of about - 50 mV, varied with changes in the [Cl](o) of the bathing medium, and was not blocked by the cholinolytics tested.3. ACh applied more distal to the soma, in the neuropile, produced a 1-3 sec monophasic response whose reversal potential was more positive than - 30 mV, varied in amplitude with changes in the [Na](o) of the medium, and was blocked by cholinolytics such as tubocurarine, hexamethonium and atropine.4. With larger iontophoretic currents a biphasic response could be obtained, depolarization followed by hyperpolarization, which represented a superposition of the above monophasic potentials.5. The cholinomimetics propionylcholine and butyrylcholine caused a biphasic response like that to ACh. "

01/01/2022 - "The major pathophysiological changes include accumulation of beta-amyloid plaques (Aβ), highly phosphorylated tau protein, neuroinflammation, GABA neurotransmission disruption, mitochondrial dysfunction, neuronal damage due to free radicals, and decreased concentration of acetylcholine (ACh) and butyrylcholine (BCh). "

01/01/2021 - "Then, antioxidant (FRAP, CUPRAC, and DPPH), antimicrobial (3 Gram (-), 4/6 Gram (+), one tuberculosis and one fungus), and enzyme inhibition (acetylcholinesterase, butyrylcholine esterase, tyrosinase, α-amylase, and α- glucosidase) for the all synthesized compounds ( 1-25 ) were evaluated. "