asiatic acid

01/01/2007 - "Topical application of asiatic acid prior to each application of TPA resulted in a significant reduction in skin tumor formation. "
11/01/2021 - "This study provides evidence that asiatic acid has strong anticancer effects to reverse multidrug resistance and could be developed as a promising adjuvant drug for the treatment of chemoresistant cancer."
01/01/2020 - "The xenografted tumor models in nude mice were established to study the antitumor activity of asiatic acid. "
01/01/2014 - "Previous studies have suggested anti-tumor effects of asiatic acid in some human cancer cell lines. "
08/01/2009 - "The present work studies asiatic acid-mediated growth inhibition of cancer cells and the underlying mechanism. "

09/15/2022 - "Asiatic acid (AA), a natural compound derived from Centella asiatica, exhibited potent anti-fibrosis effects. "
09/01/2019 - "Asiatic acid (AA) has been suggested to inhibit pulmonary and hepatic fibrosis, while its influence on cardiac fibrosis remains unclear. "
05/23/2022 - "Asiatic acid from Cyclocarya paliurus regulates the autophagy-lysosome system via directly inhibiting TGF-β type I receptor and ameliorates diabetic nephropathy fibrosis."
09/01/2013 - "Asiatic acid ameliorates tubulointerstitial fibrosis in mice with ureteral obstruction."
12/01/2020 - "In this study, we showed that asiatic acid (AA) treatment reduced chondrocyte hypertrophy and fibrosis. "

07/15/2016 - "The present study investigated the therapeutic efficacy of asiatic acid (AA) on spinal cord injury (SCI) as well as the underlying mechanisms. "
01/01/2017 - "Effect of Asiatic Acid on the Treatment of Spinal Cord Injury: An Experimental Study in Rats."
12/01/2016 - "Protective Effects of Asiatic Acid Against Spinal Cord Injury-Induced Acute Lung Injury in Rats."
12/01/2016 - "The biological effects of asiatic acid (AA) on spinal cord injury (SCI)-induced acute lung injury (ALI) have not been investigated. "
07/15/2016 - "Neuroprotective effect of asiatic acid against spinal cord injury in rats."

06/01/2009 - "Further lead optimization based on 1 is needed to find more effective asiatic acid derivatives as antidiabetic agents with protective effects against ischemic diabetic complications."
05/01/2018 - "Several medicinal compounds including ascorbic acid, asiatic acid, oleanolic acid, stevioside, stigmasterol, and α-humulene were identified in the crude extract of CA. Findings from this study suggest CA may protect diabetic tissues from stress via antioxidant and anti-inflammatory mechanisms that can be useful in the management of diabetic complications."

01/16/2014 - "Asiatic acid significantly improved insulin sensitivity, lipid profiles, hemodynamic parameters, oxidative stress markers, plasma TNF-α, NOx, and recovered abnormality of eNOS/iNOS expressions in MS rats (p<0.05). "
05/21/2014 - "Asiatic acid ameliorates hepatic lipid accumulation and insulin resistance in mice consuming a high-fat diet."
11/15/2018 - "Pentacyclic triterpenes, such as asiatic acid, ursolic acid, oleanolic acid, 18β-glycyrrhetinic acid, α,β-amyrin, celastrol, carbenoxolone, corosolic acid, maslinic acid, bardoxolone methyl and lupeol downregulate several metabolic syndrome components by regulating transcription factors, protein kinases and enzyme involved in the adipogenesis, lipolysis, fatty acid oxidation, insulin resistance, mitochondria biogenesis, gluconeogenesis, oxidative stress and inflammation. "