amidephrine

RN given refers to parent cpd without isomeric designation; structure

Also Known As:

3-(2-methylamino-1-hydroxyethyl)methanesulfonanilide; amidefrine; amidephrine monohydrochloride, (+)-isomer; amidephrine monohydrochloride, (+-)-isomer; amidephrine monohydrochloride, (-)-isomer; amidephrine, (+-)-isomer; amidephrine, (-)-isomer; N-(3-(1-hydroxy-2-(methylamino)-ethyl)phenyl)methanesulfonamide

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Amino Alcohols: 20
    - Ethanolamines: 16
      - amidephrine: 6
- Alcohols: 595
  - Ethanol: 23169
    - Ethanolamines: 16
      - amidephrine: 6
  - Amino Alcohols: 20
    - Ethanolamines: 16
      - amidephrine: 6

Experts

1.	Blue, D R: 1 article (01/2004)
2.	Daniels, D V: 1 article (01/2004)
3.	Ford, A P D W: 1 article (01/2004)
4.	Gever, J R: 1 article (01/2004)
5.	Jett, M F: 1 article (01/2004)
6.	O'Yang, C: 1 article (01/2004)
7.	Tang, H M: 1 article (01/2004)
8.	Williams, T J: 1 article (01/2004)

Related Diseases

1.	Tachycardia (Tachyarrhythmias) 10/01/1998 - "3. The combined administration of amidephrine (3 microg kg(-1) min(-1)) and isoprenaline (0.3 microg kg(-1) min(-1)) evoked a potentiated increase in insulin plasma levels in the face of a weak hyperglycaemia, an established reduction in blood pressure and tachycardia. " 09/01/1986 - "A component of the tachycardia was mediated by alpha 1-adrenoreceptors since the tachycardia to phenylephrine in the presence of propranolol was antagonised by prazosin and mimicked by the alpha 1-adrenoreceptor agonist amidephrine. "
2.	Stress Urinary Incontinence 01/01/2004 - "To describe the preclinical pharmacology of Ro 115-1240, a peripherally acting selective alpha1A/1L-adrenoceptor (AR) partial agonist, compared with the alpha1A/1L-AR full agonist amidephrine, as AR agonists have some utility in the treatment of stress urinary incontinence (SUI) but are limited by undesirable cardiovascular and central nervous system side-effects. "
3.	Neoplasms (Cancer) 01/01/1983 - "The estimated affinity and number of sites (KD = 6.3 +/- 0.9 nM; Bmax = 224 +/- 28 fmol/mg protein) as well as the relative potencies of adrenergic agonists (clonidine greater than phenylephrine greater than amidephrine) and adrenergic antagonists (yohimbine greater than dihydroergotamine much greater than prazosin) to displace [3H]yohimbine binding indicate that the yohimbine sites of these cancer cells have similar characteristics to the alpha 2-adrenergic receptors described in other tissues."
4.	Contracture 12/01/1978 - "One of the inhibitory responses was the reduction by the selective alpha-agonist amidephrine of carbachol contractures of isolated guinea-pig taenia caeci. "
5.	Anorexia 01/01/1993 - "These results document that systemic injection of the alpha 1-adrenoceptor agonists amidephrine and SK&F 89748 induces anorexia with amidephrine exerting greater potency than SK&F 89748. "

Related Drugs and Biologics

1.	Prazosin (Minipress)
2.	Phenylephrine (Neo-Synephrine)
3.	Adrenergic Antagonists (Antiadrenergic Agents)
4.	Yohimbine (Yocon)
5.	Adrenergic Receptors (Adrenergic Receptor)
6.	Proteins (Proteins, Gene)
7.	Propranolol (Inderal)
8.	Isoproterenol (Isoprenaline)
9.	Insulin (Novolin)
10.	Dihydroergotamine (Agit)