pirinixil (BR 931)

structure

Also Known As:

BR 931; 4-chloro-6-(2,3-xylidine)-2-pyrimidinylthio(N-beta-hydroxyethyl)acetamide; BR-931; 2-((4-chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)-N-(2-hydroxyethyl)acetamide

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - pirinixil: 5

Related Diseases

1.	Hyperlipidemias (Hyperlipidemia) 05/01/1978 - "BR-931 was particularly effective in diet-induced hyperlipidemias. " 05/01/1978 - "BR-931, a potent inducer of liver peroxisones and of mitochondrial carmitine acetyltransferase, appears to be a hypolipidemic agent of high efficacy and low toxicity for the clinical treatment of hyperlipidemias and atherosclerosis." 05/01/1978 - "BR-931 [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio-(N-beta-hydroxyethyl)-acetamide], a new hypolipidemic agent of low toxicity, was evaluated in several tests of lipolysis and hyperlipidemia in rats, and in the cholesterol-induced atherosclerosis in rabbits. " 05/01/1978 - "Significant hypolipidemic activity was observed in rats with doses of the agent at 12.5--50 mg/kg. In the Triton-induced hyperlipidemia, 50 mg BR-931 per kg was equieffective as 200 mg of clofibrate (CPIB) per kg. In contrast with CPIB, BR-931 exerted a powerful antilipolytic activity against epinephrine, ACTH, nicotine and cold exposure. "
2.	Hepatocellular Carcinoma (Hepatoma) 02/01/1992 - "ECH and other peroxisomal enzymes such as acyl CoA oxidase, catalase and carnitine-dependent acetyltransferase were also either not or only weakly expressed in most hepatic hyperplastic nodules and hepatomas induced by ciprofibrate (0.025% in diet), Wy-14,643 (0.1%) or BR-931 (0.2%), while being strongly induced in surrounding hepatocytes. " 09/01/1988 - "To ascertain whether the absence of immunocytochemically detectable GST-P and GGT proteins in peroxisome proliferator-induced neoplastic lesions is due to the absence of specific mRNAs, we analyzed the total RNA isolated from hepatocellular carcinomas induced by three different peroxisome proliferators (ciprofibrate, Wy-14643, and BR-931) and the genotoxic carcinogens, 2-acetylaminofluorene and aflatoxin B1 (AFB), for the presence of GST-P, GGT, and alpha-fetoprotein (AFP) mRNAs. "
3.	Atherosclerosis 05/01/1978 - "BR-931, a potent inducer of liver peroxisones and of mitochondrial carmitine acetyltransferase, appears to be a hypolipidemic agent of high efficacy and low toxicity for the clinical treatment of hyperlipidemias and atherosclerosis." 05/01/1978 - "BR-931 [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio-(N-beta-hydroxyethyl)-acetamide], a new hypolipidemic agent of low toxicity, was evaluated in several tests of lipolysis and hyperlipidemia in rats, and in the cholesterol-induced atherosclerosis in rabbits. "
4.	Hyperlipoproteinemias 09/01/1981 - "Pilot study of pirinixil (BR 931) in various forms of hyperlipoproteinemias."
5.	Hepatomegaly 07/01/1978 - "The hepatomegaly and peroxisome proliferation induced by BR-931 were comparable in degree to those resulting from feeding of an equivalent dose of Wy-14,643. "

Related Drugs and Biologics

1.	pirinixic acid
2.	Acetyltransferases
3.	ciprofibrate
4.	pirinixil (BR 931)
5.	Acyl-CoA Oxidase
6.	Peroxisome Proliferators
7.	Aflatoxin B1 (Aflatoxin B)
8.	2-Acetylaminofluorene (2 Acetylaminofluorene)
9.	RNA (Ribonucleic Acid)
10.	Proteins (Proteins, Gene)