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2- (N,N- dimethylamino)- 6,7- dihydroxytetralin (TL 99)
Also Known As:
TL 99
; 2-(NN-dimethyl)amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene; 6,7-dihydroxy-2-dimethylaminotetralin; TL-99; 2,3-Naphthalenediol, 6-(dimethylamino)-5,6,7,8-tetrahydro-
Networked:
5
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
Tetrahydronaphthalenes: 1
2-(N,N-dimethylamino)-6,7-dihydroxytetralin: 5
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
Tetrahydronaphthalenes: 1
2-(N,N-dimethylamino)-6,7-dihydroxytetralin: 5
Related Diseases
1.
Glucose Intolerance
09/01/1984 - "
Adrenodemedullation blocked the glucose intolerance and inhibition of insulin release caused by RDS-127, whereas these effects of TL-99 were not attenuated.(ABSTRACT TRUNCATED AT 250 WORDS)
"
2.
Tachycardia (Tachyarrhythmias)
09/01/1982 - "
3 M-7 (3 micrograms/kg i.v.), but neither NNPD (1 mg/kg i.v.) nor TL-99 (1-30 micrograms/kg), inhibited tachycardia evoked by low frequency electrical stimulation of the spinal cord in the pithed rat.
"
09/01/1982 - "
The effects of the dopamine agonists TL-99, M-7 (N, N-dimethyl analogues of aminotetralins) and N, N-dinpropyldopamine (NNPD) on stimulation-evoked pressor responses and tachycardia in pithed Sprague-Dawley rats were investigated when pressor responses to the compounds per se had subsided.
"
3.
Parathyroid Neoplasms (Parathyroid Neoplasm)
12/01/1991 - "
In all these cases parathyroid neoplasms were preoperatively localized (by ultrasonography, CT scan and radioactive 201-Tl 99-Tc scan) and surgically removed.
"
4.
Hypotension (Low Blood Pressure)
08/01/1978 - "
Some of the more striking actions of TL-99 and M-7 were bradycardia, hypotension and complete blockade of norepinephrine-induced reflex activation.
"
5.
Contracture
06/01/1983 - "
The alpha 2-adrenoreceptor agonists UK 14304 or TL 99 increased extracellular electrical activity and associated mechanical phasic activity without inducing sustained contracture.
"
06/01/1983 - "
Prazosin was a potent, competitive antagonist of contracture to NA, or PE, but did not antagonise the phasic responses to NA, UK 14304 or TL 99, except at high concentrations.
"
Related Drugs and Biologics
1.
5,6-dihydroxy-2-dimethylaminotetralin (M 7)
2.
Dopamine Agonists (Dopamine Agonist)
3.
Prazosin (Minipress)
4.
Norepinephrine (Noradrenaline)
5.
Insulin (Novolin)
6.
Brimonidine Tartrate (Alphagan)
7.
2- N,N- di- n- propylamino- 4,7- dimethoxyindan