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RU 31156
inhibitor or experimental immediate hypersensitivity
Also Known As:
7-(S-methylsulfonimidoyl)-5-(n-hexyl)-xanthen- 9-one-2-carboxylic acid, tris(hydroxymethyl) aminomethane salt; RU-31156; 9H-Xanthene-2-carboxylic acid, 5-hexyl-7-(S-methylsulfonimidoyl)-9-oxo-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
3-Ring Heterocyclic Compounds
Xanthenes: 65
RU 31156: 2
Related Diseases
1.
Immediate Hypersensitivity
07/01/1984 - "
Inhibition of immediate hypersensitivity reaction by a new drug, RU-31156.
"
02/01/1978 - "
Inhibition of experimental immediate hypersensitivity reactions by a novel xanthone, RU 31156.
"
02/01/1978 - "
RU 31156, the tris-(hydroxymethyl)-aminomethane salt of 7-(S-methylsulphonimidoyl)-5-(n-hexyl)-xanthen-9-one-2-carboxylic acid has been found to be a potent inhibitor of experimental immediate hypersensitivity reactions in vivo.
"
2.
Hypersensitivity (Allergy)
07/01/1984 - "
The effects of RU-31156 on type I allergic reactions were studied and the following results were obtained.
"
3.
Asthma (Bronchial Asthma)
07/01/1984 - "
Orally-administered RU-31156 gave significant inhibition of induction of experimental asthma symptoms in guinea pigs when it was given one or two hours prior to challenge.
"
4.
Anaphylaxis (Anaphylactic Shock)
02/01/1978 - "
Anaphylactic bronchoconstriction in the guinea-pig was not affected by RU 31156 and pinnal anaphylaxis was inhibited at only relatively high doses of 1--10 mg/kg i.v. The effects of both histamine and 5-hydroxytryptamine in the mouse pinna were not affected by RU 31156.
"
Related Drugs and Biologics
1.
Tromethamine (Trometamol)
2.
Serotonin (5 Hydroxytryptamine)
3.
Salts
4.
Histamine (Histamine Dihydrochloride)
5.
Acids
6.
xanthone