sulprostone

structure

Also Known As:

16-phenoxy-omega-17,18,19,20-tetranor-PGE2 methylsulfonylamide; 16-phenoxytetranor-PGE2 methylsulfonylamide; 34.089 Pfizer; 5Z,13E-18R,11R,12R,15R- dihydroxy-9-oxo-16-phenoxy-17,18,19,20-tetranor- 5,13-prostadienoic acid methylsulfonylamide; CP-34089; Nalador; SHB 286; ZK-57671; sulproston

Networked: 139 relevant articles (9 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rudd, John A: 3 articles (01/2020 - 09/2003)
2.	Morel, Olivier: 3 articles (07/2017 - 06/2008)
3.	Bayoumeu, F: 3 articles (12/2014 - 10/2002)
4.	Ngan, Man P: 2 articles (01/2020 - 09/2003)
5.	Jones, Robert L: 2 articles (05/2017 - 09/2003)
6.	Kan, Kelvin K W: 2 articles (05/2017 - 09/2003)
7.	Deneux-Tharaux, Catherine: 2 articles (03/2016 - 08/2011)
8.	Dupont, Corinne: 2 articles (03/2016 - 08/2011)
9.	Goffinet, François: 2 articles (03/2016 - 01/2013)
10.	Mignon, Alexandre: 2 articles (03/2016 - 01/2013)

Related Diseases

1.	Fetal Death 11/01/2008 - "We found sulprostone an efficient drug for termination of pregnancy with fetal death in second and early third trimester of pregnancy." 11/01/2008 - "Use of intravenous sulprostone for the termination of pregnancy with fetal death in second and early third trimester of pregnancy." 03/01/1990 - "[The use of sulprostone for voluntary interruption of gestation and in intrauterine fetal death]." 03/01/1988 - " In regimen 1, 9 women with intact pregnancy and 3 with intrauterine fetal death were given Sulprostone 500 mcg 3 times at 4-hour intervals to be repeated after 24 hours if abortion did not occur. " 08/11/1978 - "Labour was induced in 20 cases of intrauterine fetal death by either intravenous (11) or intramuscular (9) administration of Sulprostone. "
2.	Amenorrhea 03/01/1990 - "The paper attempts to assess the efficacy of Sulprostone as a preoperative dilator of the uterine cervix in the +VIG operations performed both before and after the 90th day of amenorrhea and in cases of intrauterine fetal death. " 01/01/1991 - " The drug sulprostone was used to terminate a pregnancy due to fetal death in utero after 27 weeks of amenorrhea. " 01/01/1991 - "It was Sulprostone used to terminate a pregnancy because of fetal death in utero after 27 weeks of amenorrhea. " 04/01/1994 - "The sequential use of oral mifepristone and IM injection of sulprostone is effective in inducing abortion up to 7 weeks of amenorrhea. " 04/01/1994 - "To investigate the use of oral mifepristone (RU486; Roussel-Uclaf, Paris, France) associated with IM injection of sulprostone (Schering, Lys-Lez-Lannoy, France) for the induction of legal abortion (7 weeks of amenorrhea in France). "
3.	Vomiting 07/01/1980 - " The incidence of vomiting was .4-2.2 times per patient in the various study groups when a clinically effective dose of sulprostone was administered." 05/15/2017 - "In the present studies we used the ferret and sulprostone (30µg/kg, i.p.) to investigate the role of EP3/1 receptors in mechanisms of emesis and defaecation. " 01/01/2020 - "Behaviorally, sulprostone induced emesis and caused defecation. " 05/15/2017 - "These data suggests that the action of sulprostone to induce emesis and defaecation and/or tenesmus is largely independent of the abdominal vagal system, with emesis involving central mechanisms. " 05/15/2017 - "Bilateral abdominal vagotomy was ineffective to reduce sulprostone (30µg/kg, i.p.)-induced emesis and defaection and/or tenesmus. "
4.	Hemorrhage 08/22/2023 - "The French College of Gynecologists and Obstetricians (CNGOF) recommends the use of intrauterine tamponade balloon (IUTB) in postpartum haemorrhage for bleeding that is refractory after sulprostone before either surgery or interventional radiology. " 05/18/2023 - "In the control group, the sulprostone infusion was started alone within 15 minutes of randomization, and if bleeding persisted 30 minutes after the start of sulprostone infusion, intrauterine tamponade using the ebb balloon was performed. " 01/01/2013 - "Bleeding was controlled with sulprostone alone in 90 patients (63%). " 01/01/1995 - "[Practical use of sulprostone in the treatment of hemorrhages during delivery]." 05/01/1992 - " The higher doses of sulprostone had a significant effect on duration of bleeding (e.g., 9.1 days for 0.5 mg vs. 7.1 days for 0.125 mg p .001). "
5.	Uterine Inertia 11/01/2011 - "For only uterine atony (n=71), there was a slight improvement in the prescription of sulprostone within 30 minutes (53 and 58%), and improved decision within 2 hours (47 and 69%). " 10/01/2004 - "We report an analytical study over a period of 18 months and gathering 60 cases of haemorrhage of the delivery by uterine inertia having imposed the recourse to the sulprostone. " 12/01/2014 - "Balloon intra-uterine tamponade appears to be an efficient mechanical treatment of uterine atony in case of failure of the initial management by sulprostone. " 06/01/2008 - "Only two patients had uterine atony, and inefficiency of sulprostone was observed in all patients. " 10/01/2004 - "[Sulprostone in the treatment of uterine inertia. "

Related Drugs and Biologics

1.	sulprostone
2.	Dinoprostone (PGE2)
3.	Misoprostol (Cytotec)
4.	Mifepristone (RU 486)
5.	Synthetic Prostaglandins (Prostaglandin Analogues)
6.	gemeprost
7.	methylethylcellulose
8.	Prostaglandins
9.	Oxytocin (Pitocin)
10.	Prostaglandins E

Related Therapies and Procedures

1.	Intravenous Infusions
2.	Therapeutic Abortion
3.	Operative Surgical Procedures
4.	Ligation
5.	Hysterectomy