santamarine

sesquiterpene derivative of costunolide

Also Known As:

santamarin; Naphtho(1,2-b)furan-2(3H)-one, 3a,4,5,5a,6,7,9a,9b-octahydro-6-hydroxy-5a,9-dimethyl-3-methylene-, (3aS-(3aalpha,5abeta,6beta,9aalpha,9bbeta))-

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - santamarine: 7

Experts

1.	Khan, Muhammad: 2 articles (01/2017 - 01/2017)
2.	Fang, Jianguo: 1 article (01/2021)
3.	Gao, Kun: 1 article (01/2021)
4.	Xu, Qianhe: 1 article (01/2021)
5.	Yang, Hong-Ying: 1 article (01/2021)
6.	Yang, Minghao: 1 article (01/2021)
7.	Zhang, Junmin: 1 article (01/2021)
8.	Ma, Tonghui: 1 article (01/2017)
9.	Maryam, Amara: 1 article (01/2017)
10.	Mehmood, Tahir: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Santamarine targeting TrxR reveals its previously unrecognized mechanism of antitumor and provides a basis for the further development of santamarine as a potential cancer therapeutic agent." 07/01/2012 - "Among them, isoalantolactone (3) and santamarine (6) exhibited significant growth inhibitory activities against gynecologic cancer cell lines, while others weakly inhibited the growth of the cell lines (IC50 < or = 100 microM). " 01/01/2017 - "In the present study, we have explored the potential anti-cancer activity of a novel sesquiterpene lactone compound "santamarine" (STM) in HepG2 cells. " 01/01/2021 - "We present herein that natural product santamarine targeted thioredoxin reductase (TrxR) to weaken its antioxidative function in cells, accompanied by accumulation of high levels of reactive oxygen species (ROS), and finally induced a new mechanism of tumor cell oxidative stress-mediated apoptosis. "
2.	Colorectal Neoplasms (Colorectal Cancer) 10/01/1996 - "praeteritum: 1 alpha, 6 alpha -dihydroxyisocostic acid methyl ester (2), 1 alpha-hydroxy-1-deoxoarglanine (3), douglanin (5), santamarin (6), reynosin (7), 1-epitatridin B (8), ludovicin A (10), armexin (12), armefolin (13), armexifolin (14), and 3 alpha-hydroxyreynosin (15) were tested against the human lung carcinoma cell line GLC4 and the colorectal cancer cell line COLO 320 as well as against the bacteria Bacillus subtilis, Staphylococcus aureus, Proteus mirabilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus, beta-hemolytic Streptococcus, and the yeast Candida albicans. "
3.	Liver Neoplasms (Liver Cancer) 01/01/2017 - "Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress."
4.	Inflammation (Inflammations) 07/01/2012 - "Furthermore, santamarin induced heme oxygenase (HO)-1 expression mRNA and protein level that plays a cytoprotective role against inflammation. "
5.	Colonic Neoplasms (Colon Cancer) 06/01/2009 - "Santamarine, 9beta-acetoxycostunolide and 9beta-acetoxyparthenolide inhibited the growth of L1210 murine leukaemia, CCRF-CEM human leukaemia, KB human nasopharyngeal carcinoma, LS174T human colon adenocarcinoma and MCF 7 human breast adenocarcinoma cells in vitro, with IC(50) in the range of 0.16-1.3 microg/mL. In L1210 model, santamarine and 9beta-acetoxycostunolide inhibited L1210 cell growth, colony formation and [(3)H]-thymidine incorporation in time- and concentration-dependent manners. "

Related Drugs and Biologics

1.	Sesquiterpenes
2.	Lactones
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	Thymidine
5.	Thioredoxin-Disulfide Reductase
6.	Messenger RNA (mRNA)
7.	Proteins (Proteins, Gene)
8.	Heme Oxygenase (Decyclizing) (Heme Oxygenase)
9.	Esters
10.	Acids