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lycopodine

Also Known As:

(16R)-methyllycopodan-5-one

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - lycopodine: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolizines: 1
      - lycopodine: 1

Experts

1.	Bishayee, Kausik: 1 article (01/2013)
2.	Boujedaini, Naoual: 1 article (01/2013)
3.	Chakraborty, Debrup: 1 article (01/2013)
4.	Ghosh, Samrat: 1 article (01/2013)
5.	Khuda-Bukhsh, Anisur Rahman: 1 article (01/2013)

Related Diseases

1.	Neoplasms (Cancer) 01/05/2013 - "This study aims to check if lycopodine has demonstrable anti-cancer effects and if it has, to find out the possible mechanism of its action. " 01/05/2013 - "The overall results suggest that lycopodine is a promising candidate suitable for therapeutic use as an anti-cancer drug." 01/05/2013 - "Administration of lycopodine down-regulated the expression of 5-lipoxygenase and the 5-oxo-ETE receptor (OXE receptor1) and EGF receptor, and caused up-regulation of cytochrome c with depolarization of mitochondrial inner membrane potential, without palpable change in p53 activity, resulting in apoptosis, cell arrest at G0/G1 stage and ultimately reduced proliferation of cancer cells; concomitantly, there was externalization of phosphotidyl serine residues. "
2.	Prostatic Neoplasms (Prostate Cancer) 01/05/2013 - "To combat this situation, lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatum spores, was tested against hormone sensitive (LnCaP) and refractory (PC3) prostate cancer cells in vitro. " 01/05/2013 - "Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: signaling cascade and drug-DNA interaction."

Related Drugs and Biologics

1.	ErbB Receptors (EGF Receptor)
2.	Therapeutic Uses
3.	Cytochromes c (Cytochrome c)
4.	Serine (L-Serine)
5.	Hormones (Hormone)
6.	DNA (Deoxyribonucleic Acid)
7.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
8.	Androgens
9.	5-oxo-eicosatetraenoic acid