|1.||Boujedaini, Naoual: 1 article (01/2013)|
|2.||Bishayee, Kausik: 1 article (01/2013)|
|3.||Chakraborty, Debrup: 1 article (01/2013)|
|4.||Ghosh, Samrat: 1 article (01/2013)|
|5.||Khuda-Bukhsh, Anisur Rahman: 1 article (01/2013)|
01/05/2013 - "This study aims to check if lycopodine has demonstrable anti-cancer effects and if it has, to find out the possible mechanism of its action. "
01/05/2013 - "The overall results suggest that lycopodine is a promising candidate suitable for therapeutic use as an anti-cancer drug."
01/05/2013 - "Administration of lycopodine down-regulated the expression of 5-lipoxygenase and the 5-oxo-ETE receptor (OXE receptor1) and EGF receptor, and caused up-regulation of cytochrome c with depolarization of mitochondrial inner membrane potential, without palpable change in p53 activity, resulting in apoptosis, cell arrest at G0/G1 stage and ultimately reduced proliferation of cancer cells; concomitantly, there was externalization of phosphotidyl serine residues. "
|2.||Prostatic Neoplasms (Prostate Cancer)
01/05/2013 - "To combat this situation, lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatum spores, was tested against hormone sensitive (LnCaP) and refractory (PC3) prostate cancer cells in vitro. "
01/05/2013 - "Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: signaling cascade and drug-DNA interaction."
|1.||Cytochromes c (Cytochrome c)
|3.||Epidermal Growth Factor Receptor (EGF Receptor)
|5.||DNA (Deoxyribonucleic Acid)
|6.||Arachidonate 5-Lipoxygenase (5 Lipoxygenase)