indole-3-carbinol

02/01/2000 - "Analysis of the biological effects of the Cruciferae diet has helped start clinical studies of indole-3-carbinol as an antitumor and anticarcinogenic remedy for patients with a high risk of tumor diseases."
06/04/2018 - "Future clinical trials will be needed to clarify the usefulness of indole-3-carbinol in this cancer and to understand the molecular mechanisms involved."
06/01/2017 - "Previous studies have demonstrated that indole-3-carbinol inhibits the proliferation and induces apoptosis of various tumor cells. "
07/01/2013 - "As in previous studies, indole-3-carbinol (I3C, feed to the dam at 100, 500 or 1000ppm), derived from cruciferous vegetables, dose-dependently reduced lung tumor multiplicity and also increased offspring survival. "
03/01/2008 - "This study was designed to investigate the effect of indole-3-carbinol (I3C) in cell lines and on PC tumor growth in mice when given as a therapeutic and as a preventive treatment. "

05/01/2013 - "Antitumoral activity of indole-3-carbinol cyclic tri- and tetrameric derivatives mixture in human breast cancer cells: in vitro and in vivo studies."
08/01/2005 - "We completed a phase I trial of indole-3-carbinol (I3C) in 17 women (1 postmenopausal and 16 premenopausal) from a high-risk breast cancer cohort. "
01/01/1997 - "Dose-ranging study of indole-3-carbinol for breast cancer prevention."
07/01/2017 - "Indole-3-carbinol was nominated by the National Cancer Institute for toxicity and carcinogenicity testing because of its occurrence in natural products and for its potential use as a breast cancer chemopreventive agent. "
01/01/2012 - "Induction of endoplasmic reticulum stress response by the indole-3-carbinol cyclic tetrameric derivative CTet in human breast cancer cell lines."

06/01/1998 - "Indole-3-carbinol is a chemical that is found in high concentrations in cruciferous vegetables and has been shown to alter the growth pattern of recurrent respiratory papillomatosis cell cultures and to be effective in an in vivo animal model of recurrent respiratory papillomatosis. "
06/01/1998 - "We report the preliminary results of a phase I trial using indole-3-carbinol for the treatment of recurrent respiratory papillomatosis. "
01/01/2011 - "It is concluded that treatment with indole-3-carbinol can be recommended as a starting therapeutic modality for the management of juvenile recurring respiratory papillomatosis and the reduction of the intervals between relapses of the disease."
06/01/2004 - "We report the results of a clinical study using Indole-3-Carbinol (I3C) for the treatment of recurrent respiratory papillomatosis (RRP). "
06/01/2004 - "Indole-3-carbinol for recurrent respiratory papillomatosis: long-term results."

04/01/2011 - "In earlier studies, we demonstrated the efficacy of indole-3-carbinol (I3C) against lung adenocarcinoma in A/J mice. "
04/01/2011 - "Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice."
12/01/2011 - "We studied the chemopreventive efficacy of indole-3-carbinol (I3C), a phytochemical found in cruciferous vegetables, to inhibit tobacco carcinogen-induced lung adenocarcinoma in A/J mice when given following post-initiation or progression protocol. "
12/01/2011 - "Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis."

07/01/2017 - "Toxicology studies of indole-3-carbinol in F344/N rats and B6C3F1/N mice and toxicology and carcinogenesis studies of indole-3-carbinol in Harlan Sprague Dawley rats and B6C3F1/N mice (gavage studies)."
02/01/2017 - "In animal studies, a protective effect of indole-3-carbinol has been demonstrated in colon carcinogenesis. "
12/11/1998 - "In this study, the antitumour promoting potential of indole-3-carbinol was studied in a two-stage mouse skin model of carcinogenesis. "
10/11/2021 - "Synbiotic supplementation attenuates the promoting effect of indole-3-carbinol on colon tumorigenesis."
07/01/2010 - "A novel mechanism of indole-3-carbinol effects on breast carcinogenesis involves induction of Cdc25A degradation."