ethynerone

Also Known As:

17-alpha-chloroethynyl-19-nor-4,9-androstadien-17-beta-ol-3-one; 19-nor-17-alpha-pregna-4,9-dien-20-yn-3-one, 21-chloro-17-hydroxy-; 21-chloro-17-hydroxy-19-nor-17 alpha-pregna-4,9-dien- 20-yn-3-one

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Norsteroids: 16
      - Norpregnanes: 2
        Norpregnadienes
        ethynerone: 4

Related Diseases

1.	Neoplasms (Cancer) 07/01/1980 - "Malignant tumors were not seen in 33 dogs administered mestranol at 0.02 and 0.05 mg/kg/day for 7 years or in 18 dogs given ethynerone without mestranol at 1.00 mg/kg/day for 5 years. " 05/01/1988 - "The mestranol and ethynerone combination produced a proliferative atypia in 22 of 52 animals (42%), including five identical to intraductal carcinoma in the human and one identical to lobular neoplasia. " 07/01/1980 - "The malignant tumors were observed in 1 dog that received ethynerone plus mestranol at 1.05 mg/kg/day and in 4 dogs that received chlorethynyl norgestrel plus mestranol at 1.05 mg/kg/day. " 09/01/1977 - " A small number of dogs that received each progestogen-mestranol combination developed clinically malignant tumors; control dogs or dogs that received only mestranol or ethynerone were unaffected. " 06/01/1978 - "Malignant neoplasms were seen in dogs given 10 and 25 times the proposed human dosage of anagestone acetate plus mestranol and 25 times the proposed human dosage of WY-4355 plus mestranol and ethynerone plus mestranol. "
2.	Fibrosarcoma 07/01/1980 - "Three dogs had single malignant mammary nodules, 3 dogs had 2 malignant nodules, 2 dogs had 4-6 malignant nodules, and 1 dog in the treatment group given high dosages of ethynerone plus mestranol had 14 mammary nodules composed of fibrosarcoma. "
3.	Diabetes Mellitus 09/01/1977 - " Diabetes mellitus occurred in 10 dogs from the chloroethynyl norgestrel-mestranol and anagestone acetate-mestranol groups and in 3 monkeys from the ethynerone-mestranol high dose and anagestone acetate-mestranol high dose groups. "
4.	Noninfiltrating Intraductal Carcinoma (DCIS) 05/01/1988 - "Eleven of 15 monkeys (73%) administered ethynerone developed proliferative atypia, ranging in degree from minimal to severe, including one invasive carcinoma and 2 lesions resembling intraductal carcinoma in the human. " 05/01/1988 - "The mestranol and ethynerone combination produced a proliferative atypia in 22 of 52 animals (42%), including five identical to intraductal carcinoma in the human and one identical to lobular neoplasia. "
5.	Carcinoma (Carcinomatosis) 05/01/1988 - "Eleven of 15 monkeys (73%) administered ethynerone developed proliferative atypia, ranging in degree from minimal to severe, including one invasive carcinoma and 2 lesions resembling intraductal carcinoma in the human. "

Related Drugs and Biologics

1.	Mestranol
2.	Acetates (Acetic Acid Esters)
3.	anagestone
4.	chloroethynyl norgestrel
5.	Progestins (Progestagens)
6.	Norgestrel (DL-Norgestrel)