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bakkenolide A

structure

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - bakkenolide A: 2

Experts

1.	Hong, Ze: 1 article (10/2016)
2.	Hu, Jian: 1 article (10/2016)
3.	Sun, Xing-Zhen: 1 article (10/2016)
4.	Wang, Xiang: 1 article (10/2016)
5.	Yuan, Yu-Fang: 1 article (10/2016)
6.	Zhang, Lei: 1 article (10/2016)
7.	Zhang, Rong-Rong: 1 article (10/2016)
8.	Gao, Kun: 1 article (08/2004)
9.	Jia, Zhong-Jian: 1 article (08/2004)
10.	Li, Er-Wei: 1 article (08/2004)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2016 - "Bakkenolide A (Bak), extracted from Petasites tricholobus, has been suggested to against cancer and display protective effects on inflammatory cytokines formation. "
2.	Leukemia 10/01/2016 - "Up-regulation of Caspase3/7 was observed in cells of HDAC3-knockdown and Bakkenolide A treatment, inducing leukemia cell apoptosis. " 10/01/2016 - "But the function of Bakkenolide A in regulating leukemia is not understood yet, particularly via HDAC3. " 10/01/2016 - "Bakkenolide A inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways." 08/01/2004 - "In addition, bakkenolide A (3) exhibited effective antitumor activity to human leukemia cells (HL-60), human hepatoma cells (Bel-7402) and human ovarian neoplasm cells (HO-8910)." 10/01/2016 - "Thus, these results indicated that Bakkenolide A-mediated HDAC3 sensitization in leukemia cells seem to be associated with activation of effector IKKs, Akt/GSK, and caspases through induction of the PI3K pathway, leading to inflammation, cell death, and apoptosis."
3.	Ovarian Neoplasms (Ovarian Cancer) 08/01/2004 - "In addition, bakkenolide A (3) exhibited effective antitumor activity to human leukemia cells (HL-60), human hepatoma cells (Bel-7402) and human ovarian neoplasm cells (HO-8910)."
4.	Inflammation (Inflammations) 10/01/2016 - "Thus, these results indicated that Bakkenolide A-mediated HDAC3 sensitization in leukemia cells seem to be associated with activation of effector IKKs, Akt/GSK, and caspases through induction of the PI3K pathway, leading to inflammation, cell death, and apoptosis." 10/01/2016 - "Moreover, Bakkenolide A was found to inhibit inflammation, induce apoptosis and cell death in leukemia cells via PI3K-regulated signaling pathway, down-regulating IKKs expression and suppressing in proinflammatory cytokines of IL-1β, IL-18 and TNF-α. "
5.	Hepatocellular Carcinoma (Hepatoma) 08/01/2004 - "In addition, bakkenolide A (3) exhibited effective antitumor activity to human leukemia cells (HL-60), human hepatoma cells (Bel-7402) and human ovarian neoplasm cells (HO-8910)."

Related Drugs and Biologics

1.	Cytokines
2.	Interleukin-18 (Interleukin 18)
3.	Caspases