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alrestatin
aldose reductase inhibitor; RN given refers to parent cpd; structure
Also Known As:
AY 22,284; alrestatin, sodium salt; 1,3-dioxo-1H-benz(de)isoquinoline-2(3H)- acetate
Networked:
3
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Isoquinolines: 34
alrestatin: 3
Related Diseases
1.
Peripheral Nervous System Diseases (PNS Diseases)
04/01/1979 - "
In normal subjects and in highly selected diabetic patients with severe peripheral neuropathy, alrestatin given either intravenously (50 mg/kg body weight) or orally (1 gm q.i.d.) produced no acute toxicity.
"
06/01/1981 - "
A single-blind, nonrandomized, placebo crossover clinical trial of an aldose reductase inhibitor, Alrestatin (AY 22, 284) was performed over a 4-mo period in nine patients with diabetic peripheral neuropathy.
"
04/01/1979 - "
Studies with the aldose reductase inhibitor alrestatin in animal models have suggested that the sorbitol pathway may be of etiologic significance in the pathogenesis of peripheral neuropathy in diabetes.
"
2.
Diabetes Mellitus
11/01/1978 - "
It is suggested that alrestatin may play a useful role in the therapy of diabetes mellitus since it can augment insulin secretion when glucose is administered to a fasted animal in which the acute insulin response has been shown to be like that of the human diabetic, and in addition, can lower arginine-stimulated glucagon secretion in the animal, the latter being a model of an action that is observed in the human diabetic.
"
3.
Body Weight (Weight, Body)
04/01/1979 - "
In normal subjects and in highly selected diabetic patients with severe peripheral neuropathy, alrestatin given either intravenously (50 mg/kg body weight) or orally (1 gm q.i.d.) produced no acute toxicity.
"
Related Drugs and Biologics
1.
Aldehyde Reductase (Aldose Reductase)
2.
Sorbitol (Yal)
3.
Insulin (Novolin)
4.
Glucose (Dextrose)
5.
Glucagon (Glukagon)
6.
Arginine (L-Arginine)
Related Therapies and Procedures
1.
Therapeutics