shikonin

a naphthazarin; has antineoplastic and angiogenesis inhibiting activities

Also Known As:

(+)-shikonin; (+-)-shikonin; (R)-(+)-shikonin; 1,4-naphthalenedione, 5,8-dihydroxy-2-((1R)-1-hydroxy-4-methyl-3-penten-1-yl)-; 1,4-naphthalenedione, 5,8-dihydroxy-2-((1r)-1-hydroxy-4-methyl-3-pentenyl)-; 1,4-naphthalenedione, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-, (R)-; 1,4-naphthoquinone, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-, (+)-; 2-((1R)-1-hydroxy-4-methyl-3-pentenyl)-5,8-dihydroxy-1,4-naphthoquinone; 5,8-dihydroxy-2-((1R)-1-hydroxy-4-methyl-3-penten-1-yl)-1,4-naphthalenedione; 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthalenedione; isoarnebin 4; shikonin, (+)-isomer

Networked: 542 relevant articles (54 outcomes, 186 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bauer, Rudolf: 11 articles (07/2022 - 05/2012)
2.	Kretschmer, Nadine: 11 articles (07/2022 - 05/2012)
3.	Yang, Ning-Sun: 10 articles (01/2018 - 04/2012)
4.	Efferth, Thomas: 9 articles (02/2022 - 01/2012)
5.	Lohberger, Birgit: 7 articles (07/2022 - 05/2012)
6.	Rinner, Beate: 6 articles (05/2022 - 05/2012)
7.	Ge, Pengfei: 6 articles (01/2022 - 01/2013)
8.	Qi, Jin-Liang: 6 articles (05/2021 - 01/2017)
9.	Hu, Xun: 6 articles (05/2018 - 05/2007)
10.	Li, Shao-Shun: 6 articles (01/2018 - 11/2008)

Related Diseases

1.	Neoplasms (Cancer) 10/01/1991 - "Shikonin mixture is safe and effective for later-stage cancer." 11/02/2023 - "In this study, we demonstrated the potent anticancer activity of shikonin derivatives in our MFS cellular model of tumor heterogeneity for developing a new therapeutic approach. " 07/01/2021 - "In vivo study also confirmed that shikonin could significantly inhibit the growth of tumor in tumor-bearing mice(P＜0.01)in dose-dependent and time-dependent manners. " 10/27/2020 - "In recent years, many studies have been conducted on the anti-tumor effect of shikonin and its derivatives, the major active components of A. " 12/01/2019 - "The in vivo trial results revealed that Shikonin determinately impeded tumor formation. "
2.	Inflammation (Inflammations) 07/01/2023 - "Shikonin ameliorates salivary gland damage and inflammation in a mouse model of Sjögren's syndrome by modulating MAPK signaling pathway." 08/23/2023 - "To the best of our knowledge, this is the first study to outline the underlying mechanism through which shikonin acts on gut microbes to alleviate acute inflammation, providing an alternative mechanism for shikonin to become a preventive agent in countering inflammation." 11/01/2020 - "The aim of the present study was to investigate the effects of shikonin at non-cytotoxic doses on the pro-inflammation functions of monocytes and macrophages. " 03/01/2014 - "To study the anti-inflammation effect of Shikonin (Shik) and its mechanism, murine macrophage-like RAW264.7 cells (RAW264.7 cells) were divided into control group, LPS group (0.125, 0.25 and 0.5μg/ml), LPS (0.125, 0.25 and 0.5μg/ml) plus Shik (0.5, 1 and 2μM) group, and Shik (2μM) group. " 12/01/2023 - "These findings showed that shikonin can improve inflammation by affecting macrophage polarization. "
3.	Colorectal Neoplasms (Colorectal Cancer) 05/01/2022 - "Our study provides evidence to support further investigations on shikonin as a therapeutic option for 5-fluorouracil-resistant colorectal cancer." 05/01/2022 - "The aim of this study was to characterize the molecular mechanisms underpinning shikonin-induced apoptosis, with a focus on endoplasmic reticulum (ER) stress, in a 5-fluorouracil-resistant colorectal cancer cell line, SNU-C5/5-FUR. " 01/01/2022 - "In this study, we demonstrated that shikonin significantly inhibited the activity of colorectal cancer cells in a time- and dose-dependent manner. " 01/01/2020 - "Our study provides new insights into the drug therapeutic strategies and a better understanding of antitumor mechanisms that might be valuable for further studies on Shikonin in the clinical treatment of colorectal cancer." 07/01/2018 - "The aim of the present study was to evaluate the ability of shikonin to prevent, in vivo, the early phases of colorectal cancer development, with special focus on its cytotoxic mechanism in vitro. "
4.	Glioma (Gliomas) 12/05/2020 - "This study aimed to systematically uncover and validate the pharmacological mechanism of Shikonin against glioma. " 12/28/2019 - "In this study, we find that shikonin induces MLKL activation and chromatinolysis in glioma cells in vitro and in vivo, which are accompanied with nuclear translocation of AIF and γ-H2AX formation. " 05/01/2019 - "The present study investigated the influence of shikonin on the proliferation and apoptosis of glioma cells U251 and U87MG and explored the potential molecular mechanisms. " 01/01/2018 - "In this study, we found shikonin activated RIP1 and RIP3 in glioma cells in vitro and in vivo, which was accompanied with glycolysis suppression. " 01/01/2014 - "In this study, we investigated the mode of oxidative stress of shikonin in human glioma cells. "
5.	Hepatocellular Carcinoma (Hepatoma) 12/01/2010 - "Shikonin inhibited HepG2 cells, possibly through the pathway of inducing early apoptosis, and was beneficial for restoring the apoptotic sensitivity of HepG2 cells by CD95, and should therefore be considered as a candidate agent for the prevention or treatment of human hepatoma." 01/01/2020 - "Experimental Study of Hepatocellular Carcinoma Treatment by Shikonin Through Regulating PKM2." 02/01/2018 - "In the present study, SMMC-7721 human hepatocellular carcinoma cells were treated with shikonin (1, 2 or 4 µM) for 12-48 h. " 05/02/2017 - "Metabolic profiling study of shikonin's cytotoxic activity in the Huh7 human hepatoma cell line." 09/01/2012 - "Our previous study demonstrated that shikonin possesses anticancer activity in human hepatoma cells. "

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9.	Paclitaxel (Taxol)
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Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Chinese Traditional Medicine (Traditional Chinese Medicine)
4.	Chemoprevention
5.	Immunotherapy