|1.||Yang, Ning-Sun: 6 articles (01/2015 - 01/2012)|
|2.||Hu, Xun: 5 articles (01/2013 - 05/2007)|
|3.||Wang, Ping: 4 articles (12/2015 - 01/2013)|
|4.||Xue, Yi-Xue: 4 articles (12/2015 - 01/2013)|
|5.||Liu, Yun-Hui: 4 articles (12/2015 - 01/2013)|
|6.||Jeong, Seo Young: 4 articles (12/2015 - 05/2014)|
|7.||Jang, Soon Young: 4 articles (12/2015 - 05/2014)|
|8.||Kim, Jong-Ho: 4 articles (12/2015 - 05/2014)|
|9.||Efferth, Thomas: 4 articles (11/2015 - 01/2012)|
|10.||Chen, Ching-Hsein: 4 articles (01/2014 - 12/2003)|
10/01/1991 - "Shikonin mixture is safe and effective for later-stage cancer."
04/01/2015 - "In this study, we investigated the anti-tumor activity of shikonin, a natural compound isolated from the Chinese plant Lithospermum erythrorhizon, against the human GC cell line HGC-27. "
01/01/2015 - "In our previous study we showed that phytochemical shikonin (SK) can drastically enhance ICD activity in mouse tumor cells treated ex-vivo, and the resultant tumor cell lysate (TCL) can effectively augment such SK-TCL pulsed DC vaccine activity in vivo in anti-tumor activities. "
01/01/2015 - "Although shikonin alone suppressed PKM2 activity, it did not suppress tumor promoter-induced PKM2 activation in the skin epidermal tissues at the end of the skin carcinogenesis study. "
01/01/2014 - "Shikonin is a compound from the herbal plant Lithospermum erythrorhizon that has been proved to possess powerful anti-proliferative effect on many kinds of cancers and to be safe in in vivo study. "
|2.||Hepatocellular Carcinoma (Hepatoma)
12/01/2010 - "Shikonin inhibited HepG2 cells, possibly through the pathway of inducing early apoptosis, and was beneficial for restoring the apoptotic sensitivity of HepG2 cells by CD95, and should therefore be considered as a candidate agent for the prevention or treatment of human hepatoma."
09/01/2012 - "Our previous study demonstrated that shikonin possesses anticancer activity in human hepatoma cells. "
12/15/2011 - "In this study, we investigated the effects of shikonin on human hepatocellular carcinoma (HCC) in vitro and in vivo. "
09/05/2014 - "Our previous data demonstrate that high doses (about 6 μM) of shikonin induce apoptosis in human hepatocellular carcinoma (HCC) cells. "
08/28/2013 - "Shikonin suppresses the migratory ability of hepatocellular carcinoma cells."
|3.||Lung Neoplasms (Lung Cancer)
07/01/2015 - "Shikonin was observed to reduce cell viability and induce apoptosis and G2/M phase arrest in lung cancer cells. "
01/01/2015 - "These results indicate the potential and dose-related cytotoxic actions of shikonin on A549 lung cancer cells via p53-mediated cell fate pathways and raise shikonin a promising adjuvant chemotherapeutic agent for treatment of lung cancer in clinical practice. "
01/01/2015 - "To fulfill this, A549 lung cancer cells were treated with shikonin and then subjected to microscopic, biochemical, flow cytometric, and molecular analyses. "
10/01/1991 - "The clinical observation showed that shikonin mixture could inhibit the growth of lung cancer and improve the immune function of the body. "
10/01/1991 - "[Clinical trial on the effects of shikonin mixture on later stage lung cancer]."
11/17/2015 - "The effect of shikonin on U937 cells was confirmed in other leukemia cell lines (Jurkat, Molt4, CCRF-CEM, and multidrug-resistant CEM/ADR5000), where shikonin also inhibited c-MYC expression and influenced phosphorylation of AKT, ERK1/2, and SAPK/JNK. "
11/17/2015 - "Here, we investigated shikonin and 14 derivatives on U937 leukemia cells. "
11/17/2015 - "Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells."
01/01/2013 - "Integration of Different "-omics" Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells."
02/01/2012 - "To explore the mechanism of shikonin for inducing the apoptosis of human promyelocytic leukemia cell HL-60. "
|5.||Breast Neoplasms (Breast Cancer)
01/01/2015 - "In the present study, the effect of shikonin on the induction of cell necroptosis or apoptosis was evaluated using the T-47D breast cancer cell line. "
01/01/2015 - "In this study, we evaluated the effects of Shikonin (Shk) on breast cancer and found its anti-CSC potential. "
06/01/2014 - "In the present study, we investigated the effect of shikonin on human breast cancer invasion and migration. "
12/01/2006 - "Thus, in the present study, whether shikonin could induce MCF-7 human breast cancer cell apoptosis was investigated. "
12/01/2015 - "Shikonin as an inhibitor of the LPS-induced epithelial-to-mesenchymal transition in human breast cancer cells."
|2.||Reactive Oxygen Species (Oxygen Radicals)
|10.||Proteasome Endopeptidase Complex (Proteasome)
|1.||Chinese Traditional Medicine (Traditional Chinese Medicine)
|2.||Drug Therapy (Chemotherapy)
|4.||Heterologous Transplantation (Xenotransplantation)
|5.||Homologous Transplantation (Allograft)