phaeomelanin

08/01/1977 - "Chromatograms of phaeomelanin precursors and of an extract of a highly pigmented hamster melanoma are also presented. "
01/01/2013 - "We conclude that melanocytes in the HGF/SF transgenic mouse, particularly in the papillary dermis, are vulnerable to UVA which interacts with eumelanin but not phaeomelanin to induce melanoma. "
01/01/2004 - "These results suggest that DLC has pigment-lightening effects on HM3KO melanoma cells, produced by reducing the level of eumelanin while increasing the level of phaeomelanin."
08/01/2003 - "Comparison of phaeomelanin and its precursor 5-S-cysteinyldopa in the serum of melanoma patients."
08/01/2001 - "Melanosomal pH controls rate of melanogenesis, eumelanin/phaeomelanin ratio and melanosome maturation in melanocytes and melanoma cells."

09/01/2003 - "Eumelanin and phaeomelanin contents of depigmented and repigmented skin in vitiligo patients."
09/01/2003 - "In a preliminary study, to quantify levels of both eumelanin and phaeomelanin in depigmented as well as repigmented patches of vitiligo following psoralen plus ultraviolet A (PUVA) therapy. "

02/01/1998 - "These results would suggest that a high UV sensitivity is associated with high phaeomelanin and low eumelanin levels, and point to the eumelanin/phaeomelanin ratio as a novel chemical parameter that could be used for predicting individuals at high risk for skin cancer and melanoma."
05/01/2005 - "Because skin cancer risk is affected by specific population-dependent phenotypes such as skin and hair colour, codon 1315 was also analysed for normal allele frequency variation in human populations having differing extents of eumelanin vs. phaeomelanin. "
08/01/2000 - "Recent advances in estimating the density of cutaneous melanin by spectrophotometry and the concentration of the two types of melanin (eumelanin and phaeomelanin) in hair offer the potential to define the risk of skin cancer in individuals more accurately. "

09/01/1978 - "It is concluded that excessive weight gain resulting in obesity is induced by the Avy gene even when phaeomelanin synthesis is completely inhibited."

02/01/2003 - "The switch from phaeomelanin to eumelanin in the fur is most likely due to out-competition of the agouti gene product by alpha-melanocyte-stimulating hormone from the pituitary tumors, an effect masked in black or agouti mice."