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isosafrole
RN given refers to cpd without isomeric designation
Also Known As:
4-propenyl-1,2-methylenedioxybenzene; 5-((1E)-1-propenyl)-1,3-benzodioxole; beta-isosafrole; isosafrol; isosafrole, (E)-isomer; 5-(1-propenyl)-1,3-benzodioxole
Networked:
11
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Allylbenzene Derivatives: 4
Safrole: 67
isosafrole: 11
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Dioxoles
Benzodioxoles: 3
Safrole: 67
isosafrole: 11
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzodioxoles: 3
Safrole: 67
isosafrole: 11
Related Diseases
1.
Cholestasis
11/01/1994 - "
In addition, sesamol, methylenedioxybenzene and isosafrole showed significant protective effects against cholestasis induced by CCl4.
"
2.
Neoplasms (Cancer)
01/01/1979 - "
By contrast, neoplasms of the forestomach were not increased in mice receiving safrole or isosafrole.
"
09/16/1985 - "
The isolated human P1-450 genomic clone hybridizes to 3-methylcholanthrene-induced mRNA from monkey liver, benzanthracene and 3-methylcholanthrene-treated human mammary tumor cells (MCF-7), but not to isosafrole-treated human cells.
"
3.
Necrosis
12/12/1997 - "
Previously it was shown that methylenedioxybenzenes (MDBs), particularly isosafrole, were highly effective at preventing CCl4-induced liver necrosis in vivo (Z.S.
"
12/12/1997 - "
In the following it was shown that pretreatment of mice with isosafrole also completely prevented ferric nitrilotriacetate (FeNTA)-induced renal necrosis and lipid peroxidation, even though metabolic activation by cytochrome P450 is not involved.
"
10/01/1996 - "
Pretreatment with isosafrole, safrole, dihydrosafrole, and benzodioxole at dosages as low as 10 mg/kg significantly prevented the increase in plasma transaminase levels and histochemical changes associated with CCl4-induced liver necrosis, whereas piperonyl butoxide (PBO), eugenol, isoeugenol, sesamol, and curcumin did not prevent CCl4 hepatotoxicity even at 200 mg/kg. However, isosafrole was only partly hepatoprotective if administered 10 min after the toxicant.
"
4.
Body Weight (Weight, Body)
03/01/1985 - "
Isosafrole but not promethazine increased the liver to body weight ratio.
"
07/01/1985 - "
High-performance liquid chromatography of hydrolysates of the hepatic DNA of male 12-day-old B6C3F1 mice killed 9 h after a single dose (0.1 mumol/g body weight) of [2',3'-3H]-1'-hydroxysafrole showed that Adducts S-Ia, S-Ib, S-II, S-IV (identified by Phillips et al. as N6-(trans-isosafrol-3'-yl)deoxyadenosine), S-V, and S-VI were present at average levels of 3.5, 7.0, 24.4, 2.9, 1.2, and 3.6 pmol/mg DNA, respectively.
"
5.
Schizophrenia (Dementia Praecox)
08/01/1984 - "
Isosafrole may provide another biochemical model for schizophrenia.
"
08/01/1984 - "
A 19-year-old man developed a schizophrenia-like psychosis after ingesting isosafrole.
"
08/01/1984 - "
Isosafrole and schizophrenia-like psychosis.
"
Related Drugs and Biologics
1.
sesamol
2.
1,3-benzodioxole
3.
Safrole (Safrol)
4.
Phenobarbital (Luminal)
5.
Isoenzymes
6.
Cytochromes
7.
Benzodioxoles
8.
Cytochrome P-450 CYP1A2 (CYP1A2)
9.
beta-Naphthoflavone
10.
Sterigmatocystin