8-((4-chlorophenyl)thio)cyclic-3',5'-AMP

lowers cAMP in heart & fat cells; cAMP-dependent kinase inhibitor

Also Known As:

8-(4-chlorophenylthio)cAMP; 8-(4-chlorothiophenyl)cyclic AMP; 8-(p-chlorophenylthio)cyclic-3',5'-AMP; 8-CPT-cAMP; 8-CTP-cAMP; 8-parachlorophenylthio cAMP; Rp-CPT-cAMPS

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Zhu: 2 articles (02/2013 - 01/2003)
2.	Hu, Jun-Pei: 2 articles (02/2013 - 02/2008)
3.	Zhu, Qi: 2 articles (02/2008 - 01/2003)
4.	Ablain, Julien: 1 article (02/2013)
5.	Chen, Li-Juan: 1 article (02/2013)
6.	Chen, Sai-Juan: 1 article (02/2013)
7.	Dong, Ying: 1 article (02/2013)
8.	Gao, Li: 1 article (02/2013)
9.	Jiao, Bo: 1 article (02/2013)
10.	Liu, Ping: 1 article (02/2013)

Related Diseases

1.	Acute Promyelocytic Leukemia 01/01/2003 - "[In vitro study of the effects of arsenic trioxide combined with 8-CPT-cAMP on differentiation induction in retinoic acid resistant acute promyelocytic leukemia cells]."
2.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 02/01/2008 - "[cAMP analogue 8-CPT-cAMP inducing differentiation in the M2b subtype of acute myeloid leukemia cell line Kasumi-1]."
3.	T-Cell Leukemia (Leukemia, T Cell) 05/14/2004 - "8-CPT-cAMP also induced Bim expression and enhanced dexamethasone-promoted apoptosis in human T-cell leukemia CEM-C7-14 (glucocorticoid-sensitive) and CEM-C1-15 (glucocorticoid-resistant) cells; increased Bim expression in 8-CPT-cAMP-treated CEM-C1-15 cells correlated with conversion of the cells from resistance to sensitivity to glucocorticoid-promoted apoptosis. "
4.	Tachycardia (Tachyarrhythmias) 08/21/1998 - "The tachycardia, hypotension and vasodilation produced by 8-CPT-cAMP were exaggerated after administration of propranolol (P < 0.05 for all comparisons). "
5.	Leukemia 02/26/2013 - "In vivo treatment of the t(11;17) APL mouse model demonstrated that 8-CPT-cAMP could significantly improve the therapeutic effect of ATRA by targeting a leukemia-initiating cell activity. "

Related Drugs and Biologics

1.	Tretinoin (Retinoic Acid)
2.	Arsenic Trioxide (Trisenox)
3.	Therapeutic Uses
4.	Proteins (Proteins, Gene)
5.	Propranolol (Inderal)
6.	Gold
7.	Glucocorticoids
8.	Epidermal Growth Factor (EGF)
9.	Dexamethasone (Maxidex)