halopredone acetate (Topicon)

RN given refers to (6beta,11beta)-isomer; structure

Also Known As:

Topicon; THS 201; THS-201; halopredone acetate, (6alpha,11beta)-isomer; 17,21-bis(acetyloxy)-2-bromo-6 beta,9- difluoro-11 beta-hydroxypregna-1,4-diene-3,20-dione

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Fluorinated Steroids: 32
      - Fluprednisolone: 4
        halopredone acetate: 7
    - Pregnanes: 9
      - Pregnadienes
        Pregnadienetriols
        Prednisolone: 12013
        Fluprednisolone: 4
        halopredone acetate: 7

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/1977 - "17,21-Bis(acetyloxy)-2-bromo-6beta,9-difluoro-11beta-hydroxypregna-1,4-diene-3,20-dione (halopredone acetate; Topicon) cream, a new synthetic corticosteroid for topical use, has been evaluated against betamethasone valerate by means of double-blind sequential study, where the patients, mainly affected with psoriasis, presented symmetrically located lesions which were treated with either the new drug or the reference cream so that each patient could serve as his own control. "
2.	Skin Diseases (Skin Disease) 01/01/1977 - "Clinical study of the relationship between dose and response to halopredone acetate in dermatoses." 12/18/1978 - "The halopredone acetate results were identical to those of th excipient, although it was found that halopredone acetate cream (Topicon) had a marked anti-inflammatory effect in animals and on human dermatoses. "
3.	Body Weight (Weight, Body) 08/01/1985 - "In the group of THS-201 2.5 mg/kg, the below findings were observed: thinning of lumbar hair, suppression in body weight gain, decrease of food consumption in both sexes and decrease of water consumption in male. " 08/01/1985 - "In the group of THS-201 12.5 mg/kg, the below findings were observed: thinning of lumbar hair, swelling of injection site, suppression in body weight gain and decrease of food consumption. "
4.	Arthritis (Polyarthritis) 01/01/1986 - "In antigen-induced arthritis in rabbits, the inhibition of swelling of inflamed joints by intra-articular injection of THS-201 (2 mg/joint) persisted more than 30 days, suggesting that the elimination of THS-201 from the injected site was very slow. " 03/01/1986 - "Selective local anti-inflammatory activity of THS-201, a new intra-articular steroid, in cotton pellet granuloma and monoarticular arthritis."
5.	Inflammation (Inflammations) 01/01/1986 - "THS-201 even at a dose of 100 mg/kg had no inhibitory effects on such inflammations when given s.c. " 01/01/1986 - "The results, which are in agreement with the findings of labeled THS-201 into arthritic joints, indicate that THS-201 can strongly inhibit recurrence of inflammation as compared with reference steroids tested.(ABSTRACT TRUNCATED AT 250 WORDS)" 01/01/1986 - "The effect of THS-201, a new intra-articular steroid, on inflammations was examined using acute, subacute and chronic experimental models, and the antiinflammatory action of THS-201 was compared with those of reference steroids such as triamcinolone acetonide (TA), methylprednisolone acetate (MPA), hydrocortisone acetate (HA) and halopredone (HP). "

Related Drugs and Biologics

1.	halopredone acetate (Topicon)
2.	Betamethasone Valerate (Betamethasone 17 Valerate)
3.	Adrenal Cortex Hormones (Corticosteroids)
4.	Steroids
5.	Triamcinolone Acetonide (Azmacort)
6.	Excipients (Suspending Agents)
7.	Antigens
8.	Methylprednisolone Acetate (Depo-Medrol)
9.	hydrocortisone acetate (Cortifoam)

Related Therapies and Procedures

1.	Intra-Articular Injections