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dihydroguaiaretic acid

lignan extracted form Larrea divaricata; inhibitory to beef heart mitochondrial succinoxidase & NADH-oxidase; RN given refers to cpd without isomeric designation
Also Known As:
dihydroguaiaretic acid, (R*,S*)-isomer; meso-dihydroguaiaretic acid; 2,3-dimethyl-1-(3'-methoxy-4'-hydroxyphenyl)-4- (3''-methoxy-4''hydroxyphenyl)butane
Networked: 20 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Son, Jong-Keun: 3 articles (02/2016 - 07/2003)
2. Seo, Chang-Seob: 2 articles (02/2016 - 03/2008)
3. Jeon, Songhee: 2 articles (11/2015 - 02/2015)
4. Jeong, Ha Jin: 2 articles (11/2015 - 02/2015)
5. Kang, Tae-Hoon: 2 articles (11/2015 - 02/2015)
6. Ferreira, Maria-José U: 2 articles (05/2012 - 02/2010)
7. Jahng, Yurngdong: 2 articles (03/2008 - 07/2003)
8. Chang, Hsun-Shuo: 1 article (01/2022)
9. Chang, Shih-Hsin: 1 article (01/2022)
10. Chen, Ih-Sheng: 1 article (01/2022)

Related Diseases

1. Inflammation (Inflammations)
01/06/2022 - "Meso-Dihydroguaiaretic Acid Ameliorates Acute Respiratory Distress Syndrome through Inhibiting Neutrophilic Inflammation and Scavenging Free Radical."
02/01/2016 - "meso-Dihydroguaiaretic acid attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma."
02/01/2019 - "A simple and rapid method, based on matrix solid-phase dispersion (MSPD) and high-performance liquid chromatography (HPLC) was developed for simultaneous determination of nine lignans, including (-)-(7R,8R)-machilin D (Wang, C., Wang, P., Chen, X., Wang, W., Jin, Y.; Saururus chinensis (Lour.) Baill blocks enterovirus 71 infection by hijacking MEK1-ERK signaling pathway; Antiviral Research, (2015); 119:47-56), dihydroguaiaretic acid (Quan, Z., Lee, Y.J., Yang, J.H., Lu,Y., Li,Y., Lee,Y.K., et al.; Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation; Journal of Ethnopharmacology, (2010); 132:143-149.), sauchinone (Zhuang, T., Liang, J.Y., Sun, J.B., Wu, Y., Huang, L.R., Qu, W.; Secondary metabolites from Saururus chinensis and their chemotaxonomic significance; Biochemical Systematics and Ecology, (2014); 56:95-98.), rel-(7S,8S,7'R,8'R)-3,3',4,4',5,5'-hexamethoxy-7.O.7',8.8'-lignan (Tsai, W.J., Shen, C.C., Tsai, T.H., Lin, L.C.; Lignans from the aerial parts of Saururus chinensis: isolation, structural characterization, and their effects on platelet aggregation; Journal of Natural Products, (2014); 77:125-131), licarin A (Cui, H., Xu, B., Wu, T., Xu, J., Yuan, Y., Gu, Q.; Potential antiviral lignans from the roots of Saururus chinensis with activity against Epstein-Barr virus lytic replication; Journal of Natural Products, (2014); 77:100-110.), manassantin A (Lu, Y., Piao, D., Zhang, H., Li, X., Chao, G.H., Park, S.J., et al.; Saucerneol F inhibits tumor necrosis factor-alpha and IL-6 production by suppressing Fyn-mediated pathways in FcepsilonRI-mediated mast cells; Food and Chemical Toxicology, (2013); 59:696-702.), saurucinol I (Kwon, O.E., Lee, H.S., Lee, S.W., Chung, M.Y., Bae, K.H., Rho, M.C., et al.; Manassantin A and B isolated from Saururus chinensis inhibit TNF-α-induced cell adhesion molecule expression of human umbilical vein endothelial cells; Archives of Pharmacal Research, (2005); 28:55-60.), manassantin B (Hwang, B.Y., Lee, J.H., Jung, H.S., Kim, K.S., Nam, J.B., Hong, Y.S., et al.; Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-κB; Planta Medica, (2003); 69:1096-01.) and licarin B (Hwang, B.Y., Lee, J.H., Nam, J.B., Hong, Y.S., Lee, J.J.; Lignans from Saururus chinensis inhibiting the transcription factor NF-κB; Phytochemistry, (2003); 64:765-771.) in Saururus chinensis. "
2. Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
3. Prostatic Neoplasms (Prostate Cancer)
4. Fatty Liver
5. Cardiovascular Diseases (Cardiovascular Disease)

Related Drugs and Biologics

1. Free Radicals
2. Lignans
3. methyl-N-dansylgalactosaminide
4. verrucosin
5. corosolic acid
6. nectandrin-B
7. Ovalbumin
8. Antioxidants
9. 4'-hydroxy-3,3',4-trimethoxylignan
10. heliobuphthalmin