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cumene (cumol)

Also Known As:
cumol; 2-phenylpropane; isopropylbenzene
Networked: 15 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. National Toxicology Program: 2 articles (01/2013 - 02/2009)
2. Ahmadi, Abbas: 2 articles (10/2012 - 01/2012)
3. Khalili, Mohsen: 2 articles (10/2012 - 01/2012)
4. Nahri-Niknafs, Babak: 2 articles (10/2012 - 01/2012)
5. Clayton, Natasha P: 2 articles (07/2008 - 07/2008)
6. Hong, Hue-Hua L: 2 articles (07/2008 - 07/2008)
7. Lahousse, Stephanie A: 2 articles (07/2008 - 07/2008)
8. Sills, Robert C: 2 articles (07/2008 - 07/2008)
9. Ton, Thai-Vu T: 2 articles (07/2008 - 07/2008)
10. Wakamatsu, Nobuko: 2 articles (07/2008 - 07/2008)

Related Diseases

1. Carcinoma (Carcinomatosis)
2. Adenoma (Adenomas)
3. Neoplasms (Cancer)
01/01/2013 - "This monograph provides an assessment of the available scientific information on cumene, including human exposure and properties, disposition and toxicokinetics, cancer studies in experimental animals, and studies of mechanisms and other related effects, including relevant toxicological effects, genetic toxicology, and mechanisms of carcinogenicity. "
01/01/2021 - "As such, mutagenicity does not appear to be an early key event in cumene-induced rodent tumors and alternate hypothesized non-mutagenic modes-of-action are presented. "
01/01/2021 - "The purpose of this review is to evaluate the literature on the genotoxicity of cumene (CAS # 98-82-8) and to assess the role of mutagenicity, if any, in the mode of action for cumene-induced rodent tumors. "
01/01/2013 - "In addition, mutations of the K-ras oncogene and p53 tumor-suppressor gene observed in cumene-induced lung tumors in mice, along with altered expression of many other genes, resemble molecular alterations found in human lung and other cancers."
01/01/2013 - "The monograph consists of two components: (Part 1) the cancer evaluation, which reviews the relevant scientific information, assesses its quality, applies the RoC listing criteria to the scientific information, and provides the NTP recommendation for listing status for cumene in the RoC, and (Part 2) the substance profile proposed for the RoC, containing the NTP's listing status recommendation, a summary of the scientific evidence considered key to reaching that decision, and data on properties, use, production, exposure, and Federal regulations and guidelines to reduce exposure to cumene. "
4. Poisoning
5. Carcinogenesis

Related Drugs and Biologics

1. cumene (cumol)
2. Piperazine
3. Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
4. Histamine (Histamine Dihydrochloride)
5. Formaldehyde (Formol)
6. Carcinogens
7. Hydrogen Peroxide (Hydroperoxide)
8. Zeaxanthins
9. 2-Propanol (Isopropyl Alcohol)
10. Acetic Acid (Vinegar)