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RFCNU
RN given refers to ribofuranosyl-cpd
Also Known As:
1-(2-chloroethyl)-3-(1'-(5'-4-nitrobenzoyl-2',3'-isopropylidene)-alpha,beta-D-ribofuranosyl)-1-nitrosourea; N-(2-chloroethyl)-1-ribofuranosyl-2',3'-isopropylidene-5'-(p-nitrobenzoate)-3-nitrosourea; RFCNU, (beta-D-ribofuranosyl)-isomer
Networked:
4
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Urea: 15015
Nitrosourea Compounds: 21
RFCNU: 4
Nitroso Compounds: 446
Nitrosourea Compounds: 21
RFCNU: 4
Related Diseases
1.
Neoplasms (Cancer)
09/16/1982 - "
One of the significant results of our study is the apparent tissular specificity of responses according to the agent given: CZT is more often efficient on the lymphatic localizations of the studied tumors (4/5 responses); RFCNU and RPCNU often proved active on hepatic metastases (17% responses).
"
09/16/1982 - "
RFCNU was shown to be effective in 8% of digestive tumors, in 1 out of 7 pancreatic cancers and in 3 out of 10 hepatic and pulmonary metastases from an undiscovered primary adenocarcinoma.
"
09/16/1982 - "
As for RPCNU, it's action resembles that of RFCNU: tumor regression lasting for over three years was obtained in a patient with hepatic metastases from a digestive carcinoma; in another patient a regression rate exceeding 50% was seen in pulmonary metastases from a rectal tumor.
"
03/01/1981 - "
Examined by flow cytofluorometric analysis, the DNA distribution of EMT 6 tumor cells was highly perturbed after one hour of in vitro incubation with: RPCNU, RFCNU, chlorozotocin (CZT) or 185 (CNCC), four new nitrosourea derivatives.
"
2.
Neoplasm Metastasis (Metastasis)
09/16/1982 - "
One of the significant results of our study is the apparent tissular specificity of responses according to the agent given: CZT is more often efficient on the lymphatic localizations of the studied tumors (4/5 responses); RFCNU and RPCNU often proved active on hepatic metastases (17% responses).
"
09/16/1982 - "
RFCNU was shown to be effective in 8% of digestive tumors, in 1 out of 7 pancreatic cancers and in 3 out of 10 hepatic and pulmonary metastases from an undiscovered primary adenocarcinoma.
"
09/16/1982 - "
As for RPCNU, it's action resembles that of RFCNU: tumor regression lasting for over three years was obtained in a patient with hepatic metastases from a digestive carcinoma; in another patient a regression rate exceeding 50% was seen in pulmonary metastases from a rectal tumor.
"
3.
Pancreatic Neoplasms (Pancreatic Cancer)
09/16/1982 - "
RFCNU was shown to be effective in 8% of digestive tumors, in 1 out of 7 pancreatic cancers and in 3 out of 10 hepatic and pulmonary metastases from an undiscovered primary adenocarcinoma.
"
4.
Adenocarcinoma
09/16/1982 - "
RFCNU was shown to be effective in 8% of digestive tumors, in 1 out of 7 pancreatic cancers and in 3 out of 10 hepatic and pulmonary metastases from an undiscovered primary adenocarcinoma.
"
5.
Leukemia L1210
01/01/1986 - "
Three new nitrosourea analogs (CNCC, RFCNU, and chlorozotocin) had comparable activities in vivo against L1210 leukemia cells.
"
01/01/1986 - "
Effects of three new nitrosourea analogs (CNCC, RFCNU and chlorozotocin) on in vivo destruction of L 1210 leukemia cells and on the immune response.
"
01/01/1985 - "
L1210 leukemia was used to compare the antitumor activities of three nitrosoureas (chlorozotocin, RFCNU and CNCC) encapsulated in liposomes with those in the free state.
"
Related Drugs and Biologics
1.
ICIG 1163
2.
N,N'- bis((2- chloroethyl)nitrosocarbamoyl)cystamine (CNCC)
3.
chlorozotocin
4.
Liposomes (Liposome)
5.
DNA (Deoxyribonucleic Acid)