T 61

for euthanasia of animals; each milliliter contains 200 mg of N-(2-(m-methoxyphenyl)-2-ethylbutyl)-gamma- hydroxybutyramide, 50 mg of 4,4'-methylenebis(cyclohexyltrimethylammonium iodide), 5 mg of tetracaine HCl, with 0.6 ml dimethylformamide in distilled water

Also Known As:

Networked: 26 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Crane, Patricia B: 1 article (01/2022)
2.	Hirsch, Sophie: 1 article (01/2022)
3.	Stephens, Alexandria R: 1 article (01/2022)
4.	Baker-Cook, Bethany I: 1 article (01/2021)
5.	Bardram, J E: 1 article (01/2021)
6.	Gulyas, L: 1 article (01/2021)
7.	Hafiz, P: 1 article (01/2021)
8.	Hestbæk, E: 1 article (01/2021)
9.	Jespersen, A E: 1 article (01/2021)
10.	Kessing, L V: 1 article (01/2021)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 08/01/1995 - "Five human breast carcinoma xenografts, MX-1, T-61, MCF-7, R-27 and Br-10, were inoculated subcutaneously into female nude mice. " 08/01/1990 - "Although KRN8602 also inhibited the growth of T-61 significantly, the antitumor activity of this agent against the other three breast carcinoma xenografts was limited. " 11/04/1996 - "In addition, curative activities were shown in the PXN/65 human ovarian cancer xenograft and the MX-1 and T-61 human breast cancer xenograft models. " 07/01/1995 - "Four human breast carcinoma xenografts, MCF-7, Br-10, T-61 and MX-1, were transplanted into female nude mice with or without pretreatment with estradiol and progesterone. " 11/01/1988 - "However, 17 beta-busramustine generated the estrogen receptor system of T-61 tumor and resulted in the endometrial hyperplasia of tumor-bearing nude mice, suggesting that this compound also has estrogenic action on transplanted human breast carcinoma and tumor-bearing host mice, besides non-estrogenic antitumor activity on human breast carcinoma xenografts."
2.	Poisoning 09/01/1989 - "[Acute poisoning by T-61. " 05/01/1990 - "Fulminant hepatic failure in poisoning due to ingestion of T 61, a veterinary euthanasia drug." 08/01/1996 - "Hepatotoxicity of N, N-dimethylformamide (DMF) in acute poisoning with the veterinary euthanasia drug T-61." 12/01/1982 - "[T 61 (Tanax) poisoning]." 05/01/1990 - "This is the first report of such severe hepatic manifestation in T 61 poisoning, the most common symptoms of which are early coma and respiratory failure due to the anesthetic and the neuromuscular blocking agent. "
3.	Neoplasms (Cancer) 11/01/1989 - "In vitro clonogenic cell assay reproduced the antitumor activity of E2, indicating that E2 directly inhibits part of the cell growth of T-61 tumors. " 11/01/1989 - "The tumor growth was significantly stimulated by E2 in 3 out of the 4 ER positive tumors, the Td of the E2 treated groups being 17.6 days for MCF-7 (control: -17.8 days), 12.8 days for R-27 (control: -12.5 days approximately 14.5 days) and 10.4 days for Br-10 (control: 14.5 days), however, in the T-61 tumor, the growth was inhibited by E2 in a dose dependent manner. " 08/01/1995 - "MX-1 and T-61 tumors regressed completely after treatment with HMM at a dose of 75 mg/kg (the maximum tolerated dose: MTD) for MX-1 and 25 mg/kg for T-61. " 07/01/1996 - "Four tumor models, T-61, Br-10, R-27 and MCF-7 were estrogen receptor (ER)-positive and their growth was estradiol-dependent. " 11/01/1988 - "However, 17 beta-busramustine generated the estrogen receptor system of T-61 tumor and resulted in the endometrial hyperplasia of tumor-bearing nude mice, suggesting that this compound also has estrogenic action on transplanted human breast carcinoma and tumor-bearing host mice, besides non-estrogenic antitumor activity on human breast carcinoma xenografts."
4.	Body Weight (Weight, Body) 08/01/1978 - "However, dogs and cats killed with T-61 at a dose of 1.0--1.5 ml/kg body weight and necropsied at 15 minutes after injection had significant gross and microscopic pathological lesions. " 08/01/1978 - "Dogs and cats killed by intravenous injection of either 0.3 ml/kg body weight T-61 or 100 mg/kg body weight pentoarbital and necropsied at less than 5 minutes or at 15 minutes after injection did not have gross or microscopic pathological changes. " 04/01/1988 - "The artifactual development of endothelial necrosis, pulmonary congestion, and oedema that has been reported in dogs, cats, and monkeys when the animals were killed with 1-1.5 ml/kg body weight of the euthanasia agent T-61 was reproduced in adult ewes of the merino breed. " 03/01/2010 - "Following clinical examination, euthanasia was performed by intravenous injection of either 40 mg pentobarbital per kg body weight (BW) (0.1 ml Eutha 77) or 0.1 ml T 61/kg BW. "
5.	Necrosis 04/01/1988 - "The artifactual development of endothelial necrosis, pulmonary congestion, and oedema that has been reported in dogs, cats, and monkeys when the animals were killed with 1-1.5 ml/kg body weight of the euthanasia agent T-61 was reproduced in adult ewes of the merino breed. " 01/01/2012 - "macaques, dogs, cats, rats, sheep) as well as in men (suicides) euthanasia performed by intravenous injection of T 61 leads to serious lesions in lung, kidney or/and liver (endothelial damage, hyperemia, oedema, necrosis). "

Related Drugs and Biologics

1.	Estrogen Receptors
2.	Pentobarbital (Nembutal)
3.	Estradiol (Delestrogen)
4.	Dimethylformamide
5.	T 61
6.	Mitomycin (Mitomycin-C)
7.	Solvents
8.	Progesterone
9.	Neuromuscular Blocking Agents
10.	Hexosaminidases (Hexosaminidase)

Related Therapies and Procedures

1.	Euthanasia (Mercy Killing)
2.	Intravenous Injections
3.	Aftercare (After-Treatment)