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spiromustine
Also Known As:
NSC 172112; spirohydantoin mustard; 1,3-Diazaspiro(4.5)decane-2,4-dione, 3-(2-(bis(2-chloroethyl)amino)ethyl)-
Networked:
9
relevant articles (
1
outcomes,
3
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
Imidazolidines: 39
Hydantoins: 306
spiromustine: 9
Organic Chemicals: 133
Hydrocarbons: 1713
Halogenated Hydrocarbons: 42
Mustard Compounds: 3
Nitrogen Mustard Compounds: 2
spiromustine: 9
Related Diseases
1.
Neoplasms (Cancer)
08/01/1986 - "
Thirty-eight patients with refractory solid tumors received spiromustine as part of a phase I trial at the Johns Hopkins Oncology Center.
"
11/01/1982 - "
Spirohydantoin mustard (I) is a rationally designed anti-tumor agent with substantial in vivo activity against intracranially implanted tumors in mice.
"
11/01/1979 - "
Response of 9L tumor cells in vitro to spirohydantoin mustard.
"
08/01/1980 - "
Spirohydantoin mustard (SHM) has been shown to cross the blood-brain barrier in dogs and has shown activity against mouse brian tumors in vivo and against 9L rat brain tumor cells in vitro.
"
08/01/1986 - "
A phase I trial of spirohydantoin mustard (NSC 172112) in patients with advanced cancer.
"
2.
Brain Neoplasms (Brain Tumor)
08/01/1985 - "
The effects of single and split doses of spirohydantoin mustard on the growth delay and cell survival of 9L rat brain tumor multicellular spheroids have been investigated.
"
08/01/1985 - "
The effect of treatment with single and split doses of spirohydantoin mustard on the growth delay of 9L rat brain tumor multicellular spheroids.
"
08/01/1980 - "
Spirohydantoin mustard (SHM) has been shown to cross the blood-brain barrier in dogs and has shown activity against mouse brian tumors in vivo and against 9L rat brain tumor cells in vitro.
"
01/01/1994 - "
Trials of agents specifically designed for brain tumors such as AZQ and spiromustine have been disappointing.
"
11/01/1979 - "
The effects of spirohydantoin mustard (SHM), a potential antitumor agent for central nervous system tumors, in the in vitro 9L rat brain tumor model were studied.
"
3.
Glioma (Gliomas)
11/01/1987 - "
Phase II study of spirohydantoin mustard for the treatment of recurrent malignant gliomas.
"
12/01/1987 - "
The malignant glioma cell line U-87MG was used for 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), aziridinylbenzoquinone (AZQ), cis-diaminodichloroplatinum (II) (cis-DDP), and spirohydantoin mustard (SHM) treatments at 37 degrees and 42 degrees C.
"
4.
Central Nervous System Neoplasms
11/01/1979 - "
The effects of spirohydantoin mustard (SHM), a potential antitumor agent for central nervous system tumors, in the in vitro 9L rat brain tumor model were studied.
"
5.
Glioblastoma (Glioblastoma Multiforme)
02/01/1986 - "
Spiromustine and intracarotid artery cisplatin in the treatment of glioblastoma multiforme.
"
Related Drugs and Biologics
1.
spiromustine
2.
Antineoplastic Agents (Antineoplastics)
3.
Alkylating Agents
4.
diaziquone (AZQ)
5.
Phenytoin (Dilantin)
6.
Mechlorethamine (Nitrogen Mustard)
7.
Cisplatin (Platino)
8.
Carmustine (FIVB)
9.
Anticonvulsants (Antiepileptic Drugs)