3-hydroxypyridinium derivative collagen crosslink; structure
Also Known As:
hydroxylysyl pyridinoline; hydroxylysylpyridinoline; Pyridinium, 4-(2-amino-2-carboxyethyl)-1-(5-amino-5-carboxy-2-hydroxypentyl)-3-(3-amino-3-carboxypropyl)-5-hydroxy-, hydroxide, inner salt
Networked: 564 relevant articles (18 outcomes, 71 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Inaba, Masaaki: 7 articles (02/2006 - 10/2002)
2. Nishizawa, Yoshiki: 7 articles (02/2006 - 10/2002)
3. Ishimura, Eiji: 7 articles (02/2006 - 10/2002)
4. Okuno, Senji: 6 articles (02/2006 - 10/2002)
5. Fraser, W D: 6 articles (12/2005 - 09/2000)
6. Yamakawa, Tomoyuki: 5 articles (02/2006 - 05/2005)
7. Sato, Y: 5 articles (08/2001 - 04/2000)
8. Delmas, P D: 4 articles (07/2006 - 01/2000)
9. Garnero, P: 4 articles (07/2006 - 06/2001)
10. Ueda, Misako: 4 articles (02/2006 - 10/2002)

Related Diseases

1. Bone Resorption
2. Prostatic Neoplasms (Prostate Cancer)
3. Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
08/01/1998 - "Levels of urinary pyridinoline and deoxypyridinoline in urine in patients with bony metastatic prostate cancer were significantly greater than levels in patients with benign prostatic hyperplasia or localized prostate cancer. "
04/01/1994 - "Urinary excretion of pyridinoline and deoxypyridinoline was significantly greater in patients with metastatic carcinoma of the prostate compared with patients with either benign prostatic hyperplasia (Mann-Whitney-Wilcoxon rank sum analysis, p < 0.00004 and 0.002, respectively) or localized prostate cancer (Mann-Whitney-Wilcoxon, p < 0.00001 and 0.00005, respectively). "
08/01/1998 - "Urinary pyridinoline and deoxypyridinoline were measured in patients with benign prostatic hyperplasia, clinically localized prostate cancer and prostate cancer with bone metastases. "
11/01/1996 - "Levels of pyridinoline and deoxypyridinoline in urine, and the level of alkaline phosphatase in serum from patients with bone metastatic prostate cancer were significantly greater than levels in patients with benign prostatic hyperplasia or localized prostate cancer. "
11/01/1997 - "Serum concentrations of the carboxyterminal propeptide of Type I procollagen (PICP), the carboxyterminal pyridinoline cross-linked telopeptide of Type I collagen (ICTP), and prostate specific antigen (PSA) were measured by radioimmunoassays in 48 patients with benign prostatic hyperplasia (BPH), 25 patients with prostate carcinoma (PCA) without bone metastases, and 36 patients with PCA and bone metastases. "
4. Neoplasm Metastasis (Metastasis)
02/01/1997 - "Pyridinoline cross-linked carboxyterminal telopeptide, an osteoclastic marker, reflected the extent of bone metastasis more accurately than PSA and other bone markers. "
07/01/1996 - "The aim of this study was to evaluate the urinary pyridinium crosslink levels in breast cancer with or without osseous involvement, and to correlate it with serial doses of CA 15-3. 285 breast cancer patients (226 free of disease and 59 with bone metastases) were measured for both pyridinoline and CA 15-3. In the metastatic patients the mean values of the two markers were significantly higher than in non evident disease patients (P = < 0.01 and p = < 0.001 respectively). "
07/01/1996 - "Abnormal values over the normal were found in 22% for pyridinoline and 11% for CA 15-3 in patients free of disease while the normal values observed in patients with bone metastases were 22% for pyridinoline and 39% for CA 15-3. Tandem dosage of CA 15-3, was highly sensitive but site-aspecific, and pyridinoline, which is bone specific, may be useful chiefly in the monitoring of breast cancer treatment, since many physiological conditions such as age, menopausal status and variation over 24 hours, and cost effectiveness will influence the use of pyridinoline during follow-up."
01/01/2003 - "The efficacy of a serum carboxyterminal pyridinoline cross-linked telopeptide of type I collagen as a quantitative screening marker for bone metastases in patients with urological malignancies."
12/01/1997 - "Levels of urine pyridinoline (U-Pyr) excretion and serum carboxy-terminal propeptide of type 1 procollagen (P1CP) in patients with bone metastasis were significantly higher than those in patients without bone metastasis (P < 0.05). "
5. Osteoporosis

Related Drugs and Biologics

1. deoxypyridinoline
2. Alkaline Phosphatase
3. Collagen Type I (Type I Collagen)
4. Osteocalcin
5. Biological Markers (Surrogate Marker)
6. Calcium
7. Collagen
8. Hydroxyproline (4 Hydroxyproline)
9. pamidronate (APD)
10. Phosphorus

Related Therapies and Procedures

1. Hormone Replacement Therapy (Therapy, Hormone Replacement)
2. Ovariectomy (Oophorectomy)
3. Transplants (Transplant)
4. Continuous Ambulatory Peritoneal Dialysis (CAPD)
5. Coronary Artery Bypass (Coronary Artery Bypass Surgery)