protein kinase modulator

stimulates phosphorylation of histones by mammalian cGPK & inhibits phosphorylation by cAPK; stimulates & inhibits protein kinase; see also records for PKIbeta and PKIgamma

Also Known As:

PKA inhibitor; cAMP-dependent protein kinase protein modulator; cGK Ibeta; cGKIbeta; cGMP-dependent protein kinase protein modulator; cyclic AMP-dependent protein kinase inhibitor; megamodulin; protein kinase inhibitor type I; protein kinase stimulatory modulator

Networked: 123 relevant articles (7 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - protein kinase modulator: 123
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - protein kinase modulator: 123

Experts

1.	Cheng, Yu-Tong: 3 articles (09/2013 - 10/2010)
2.	Li, Xiang-Dong: 3 articles (09/2013 - 10/2010)
3.	Yang, Yue-Jin: 3 articles (09/2013 - 10/2010)
4.	Zhang, Hai-Tao: 3 articles (09/2013 - 10/2010)
5.	Zhao, Jing-Lin: 3 articles (09/2013 - 10/2010)
6.	Zhou, Xin: 2 articles (01/2020 - 01/2017)
7.	Zhang, Min: 2 articles (01/2017 - 09/2007)
8.	Hong, Yanguo: 2 articles (04/2016 - 01/2013)
9.	Wang, Dongmei: 2 articles (04/2016 - 01/2013)
10.	Amini, Elham: 2 articles (10/2015 - 04/2013)

Related Diseases

1.	Hyperalgesia 03/15/1999 - "Injection of WIPTIDE (a PKA inhibitor) at 24 hr after PKACS reduced hyperalgesia, suggesting that PKACS hyperalgesia is not independently maintained by steps downstream from PKA. " 01/01/2020 - "Intrathecal injection of a PKA inhibitor not only relieved mechanical hyperalgesia, inflammatory reaction, and apoptosis in SNI rats but also inhibited p38MAPK pathway activation. " 08/01/2014 - "Spinal administration of the PKA inhibitor Rp-cAMPS during the early phase and late phase significantly delayed or reversed, respectively, TCI-induced thermal hyperalgesia and mechanical allodynia. " 04/01/2014 - "Pretreatment with H89, a protein kinase A (PKA) inhibitor, blocked IL-1β-induced mechanical allodynia but not thermal hyperalgesia. " 07/01/2011 - "In terms of EPI signalling pathways, the protein kinase A (PKA) inhibitor H-89 inhibited EPI-induced mechanical hyperalgesia in wild-type mice, whereas H-89 had no effect in mice with low GRK2 in sensory neurons (SNS-GRK2(+/-) mice). "
2.	Pain (Aches) 01/01/2016 - "Intra-ACC microinjection of a PKA inhibitor blocked the occurrence of pain memory. " 01/01/2016 - "To explore the critical role of protein kinase A (PKA) in pain memory, a PKA inhibitor was microinjected into anterior cingulate cortex (ACC) in model rats. " 07/01/2012 - "Furthermore, intrathecal H-89 (a PKA inhibitor) significantly attenuated bone cancer pain behaviors in rats. " 05/01/2011 - "When PKA inhibitor H-89 was intrathecally applied, it totally eliminated bicuculline-induced NMDARs phosphorylation, synaptic redistribution as well as pain sensitization. " 04/09/2008 - "Inhibition of the NMDA receptor-mediated synaptic component was occluded by a protein kinase A (PKA) inhibitor, consistent with our previous demonstration of PKA-dependent increased NMDA receptor function in arthritis pain-related plasticity. "
3.	Infections 11/01/2017 - "Subsequently, the importance of PKA for BTV infection was validated using a PKA inhibitor and activator. " 02/18/2011 - "10(-6) M dibutyryl-cAMP increased the level of infection and 10(-7) M PKA inhibitor decreased the level of infection by 30%. " 06/01/2003 - "Infection of HMEC with replication-deficient adenovirus containing the protein kinase A inhibitor gene (PKA inhibitor) blocked both the FI-mediated protective effects on RhoA activation and resistance changes. " 02/14/1997 - "Concordant with the activation of CFTR by only cGK II, infection with Ad-cGK II but not Ad-cGK Ibeta enabled cGMP analogs to increase CFTR phosphorylation in intact cells. " 02/14/1997 - "In contrast, infection with recombinant adenoviruses expressing cGK Ibeta or luciferase did not convey cGMP sensitivity to CFTR in IEC-CF7 cells. "
4.	Memory Disorders (Memory Loss) 10/01/2015 - "Paradoxical role of PKA inhibitor on amyloidβ-induced memory deficit." 04/01/2013 - "Altogether, these results indicate that PKA inhibitor-induced memory deficit was attenuated by a cAMP analog and that the cAMP/PKA signaling pathway has an important role for memory consolidation in fear conditioning response model." 04/01/2013 - "A cAMP analog reverses contextual and tone memory deficits induced by a PKA inhibitor in Pavlovian fear conditioning." 01/01/2020 - "The improvement in memory deficits was prevented when SG-ME was co-administeredwith either zeta inhibitory peptide (PKC-ζ inhibitor), anti-BDNF antibody, ANA-12 (TrkB antagonist), U0126 (MEK inhibitor), H-89 (PKA inhibitor), LY294002 (PI3K inhibitor) or KN-93 (CaMKII inhibitor). "
5.	Hemorrhage 01/01/2022 - "Systemic administration of a PKa inhibitor or PK ASO to SHRSP reduced hemorrhage and blood pressure, and improved neurological function and survival compared with SHRSP receiving control ASO. " 01/01/2022 - "The roles of PKa on blood pressure, hemorrhage, and survival in SHRSP were examined in rats receiving a PKa inhibitor or plasma prekallikrein antisense oligonucleotide (PK ASO) compared with rats receiving control ASO. " 04/01/2007 - "Inhibition of PKA in E2-BSA-treated trauma-hemorrhage rats by PKA inhibitor H89 prevented the E2-BSA attenuation of hepatic injury. "

Related Drugs and Biologics

1.	N- (2- (4- bromocinnamylamino)ethyl)- 5- isoquinolinesulfonamide (h89)
2.	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
3.	Calcium-Calmodulin-Dependent Protein Kinase Type 2
4.	KN 93
5.	adenosine-3',5'-cyclic phosphorothioate
6.	Mitogen-Activated Protein Kinase Kinases (MEKs)
7.	U 0126 (UO 126)
8.	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- one
9.	Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
10.	Brain-Derived Neurotrophic Factor (BDNF)

Related Therapies and Procedures

1.	Spinal Injections
2.	Isogeneic Transplantation
3.	Radiotherapy