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2- n- propyl- 4- 4- tolylamino- 1,2,3- benzotriazinium
potential antiarrhythmia agent
Also Known As:
2-n-propyl-4-4-tolylamino-1,2,3-benzotriazinium iodide; 2-n-propyl-4-p-tolylamino-1,2,3-benzotriazinium iodide; TnPBI
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Triazines: 306
2-n-propyl-4-4-tolylamino-1,2,3-benzotriazinium: 2
Related Diseases
1.
Ventricular Fibrillation
11/01/1980 - "
In guinea-pig Langendorff hearts, a benzotriazinium derivative, 2-n-propyl-4-p-tolylamino-1,2,3-benzotriazinium iodide (TnPBI), increased the ventricular refractory period, increased the ventricular fibrillation threshold to electrical stimulation and converted persistent ventricular fibrillation to sinus rhythm.
"
2.
Tachycardia (Tachyarrhythmias)
11/01/1980 - "
TnPBI also converted aconitine-induced tachyarrhythmias to sinus rhythm in the same preparation.
"
3.
Contracture
07/01/1977 - "
2 TnPBI caused contractures of frog rectus abdominis when the muscle had been depolarized with potassium chloride.
"
07/01/1977 - "
3 Experiments with TnPBI and caffeine in calcium-free Ringer suggested that both compounds produce contractures by releasing intracellular bound calcium.
"
07/01/1977 - "
1 The mode of action of 2-n-propyl-4-p-tolylamino-1,2,3-benzotriazinium iodide (TnPBI), which induced contractures of frog rectus abdominis muscle, was investigated.
"
4.
Cardiac Arrhythmias (Arrythmia)
11/01/1980 - "
In mice pretreated with TnPBI, both acutely and chronically, the amount of intravenous aconitine necessary to produce cardiac arrhythmias was increased.
"
Related Drugs and Biologics
1.
2- n- propyl- 4- 4- tolylamino- 1,2,3- benzotriazinium
2.
Potassium Chloride
3.
Calcium
4.
Caffeine (No Doz)
5.
Aconitine