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2- n- propyl- 4- 4- tolylamino- 1,2,3- benzotriazinium

potential antiarrhythmia agent

Also Known As:

2-n-propyl-4-4-tolylamino-1,2,3-benzotriazinium iodide; 2-n-propyl-4-p-tolylamino-1,2,3-benzotriazinium iodide; TnPBI

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Triazines: 306
    - 2-n-propyl-4-4-tolylamino-1,2,3-benzotriazinium: 2

Related Diseases

1.	Ventricular Fibrillation 11/01/1980 - "In guinea-pig Langendorff hearts, a benzotriazinium derivative, 2-n-propyl-4-p-tolylamino-1,2,3-benzotriazinium iodide (TnPBI), increased the ventricular refractory period, increased the ventricular fibrillation threshold to electrical stimulation and converted persistent ventricular fibrillation to sinus rhythm. "
2.	Tachycardia (Tachyarrhythmias) 11/01/1980 - "TnPBI also converted aconitine-induced tachyarrhythmias to sinus rhythm in the same preparation. "
3.	Contracture 07/01/1977 - "2 TnPBI caused contractures of frog rectus abdominis when the muscle had been depolarized with potassium chloride. " 07/01/1977 - "3 Experiments with TnPBI and caffeine in calcium-free Ringer suggested that both compounds produce contractures by releasing intracellular bound calcium. " 07/01/1977 - "1 The mode of action of 2-n-propyl-4-p-tolylamino-1,2,3-benzotriazinium iodide (TnPBI), which induced contractures of frog rectus abdominis muscle, was investigated. "
4.	Cardiac Arrhythmias (Arrythmia) 11/01/1980 - "In mice pretreated with TnPBI, both acutely and chronically, the amount of intravenous aconitine necessary to produce cardiac arrhythmias was increased. "

Related Drugs and Biologics

1.	2- n- propyl- 4- 4- tolylamino- 1,2,3- benzotriazinium
2.	Potassium Chloride
3.	Calcium
4.	Caffeine (No Doz)
5.	Aconitine