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piflutixol

RN given refers to parent cpd; synonym piflutixol refers to (Z)-isomer; structure

Also Known As:

6-fluoro-9-(3-(4-(2-hydroxyethyl)piperidino) propylidene)-2-trifluoromethyl-thioxanthene; piflutixol monohydrochloride; piflutixol, (Z)-isomer

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thioxanthenes: 11
    - piflutixol: 1
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Xanthenes: 65
      - Thioxanthenes: 11
        piflutixol: 1

Related Diseases

1.

Huntington Disease (Huntington's Disease)

03/25/1983 - "A selective loss (48%) of [3H]piflutixol binding was observed in Huntington's disease substantia nigra pars reticulata, [3H]piflutixol binding was unchanged in substantia nigra pars compacta. "
03/25/1983 - "Both [3H]spiperone binding and [3H]piflutixol binding were reduced by 45-50% in Huntington's disease putamen. "
03/25/1983 - "The loss of [3H]spiperone and [3H]piflutixol binding sites correlated with decreased GABA concentrations observed in Huntington's disease putamen. "
03/25/1983 - "Dopamine receptors were studied in post-mortem brains from control and Huntington's disease patients, using the specific binding of [3H]spiperone to dopamine D-2 receptors and [3H]piflutixol to dopamine D-1 receptors. "

Related Drugs and Biologics

1.	Spiperone
2.	Dopamine Receptors (Dopamine Receptor)
3.	gamma-Aminobutyric Acid (GABA)
4.	Dopamine (Intropin)